(E)-tert-butyl 1-(3-(4-chlorophenyl)-1-cyanopent-1-en-3-yl)-1H-indol-4-ylcarbamate

Base Information

Chemical Name:(E)-tert-butyl 1-(3-(4-chlorophenyl)-1-cyanopent-1-en-3-yl)-1H-indol-4-ylcarbamate
CAS No.:1389326-61-7
Molecular Formula:C₂₅H₂₆ClN₃O₂
Molecular Weight:435.953
Hs Code.:

Synonyms:(E)-tert-butyl 1-(3-(4-chlorophenyl)-1-cyanopent-1-en-3-yl)-1H-indol-4-ylcarbamate

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Chemical Property of (E)-tert-butyl 1-(3-(4-chlorophenyl)-1-cyanopent-1-en-3-yl)-1H-indol-4-ylcarbamate

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Technology Process of (E)-tert-butyl 1-(3-(4-chlorophenyl)-1-cyanopent-1-en-3-yl)-1H-indol-4-ylcarbamate

There total 8 articles about (E)-tert-butyl 1-(3-(4-chlorophenyl)-1-cyanopent-1-en-3-yl)-1H-indol-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2537-48-6
diethyl 1-cyanomethylphosphonate

: 1389326-58-2
tert-butyl 1-(2-(4-chlorophenyl)-1-oxobutan-2-yl)-1H-indol-4-ylcarbamate

: 1389326-61-7
(E)-tert-butyl 1-(3-(4-chlorophenyl)-1-cyanopent-1-en-3-yl)-1H-indol-4-ylcarbamate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In acetonitrile; at 20 ℃; for 2h;

Reference yield:

: 24091-92-7
methyl 2-bromo-2-(4-chlorophenyl)acetate

: 1389326-61-7
(E)-tert-butyl 1-(3-(4-chlorophenyl)-1-cyanopent-1-en-3-yl)-1H-indol-4-ylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

1.2: 3 h / 0 °C

2.1: hydrogen / 10% Pt/activated carbon / ethyl acetate / 3 h / Inert atmosphere

3.1: sodium hydrogencarbonate / 1,4-dioxane; water

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

4.2: 2 h / 0 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C

6.1: Dess-Martin periodane / dichloromethane / 2 h / 0 °C

7.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 2 h / 20 °C

With lithium aluminium tetrahydride; hydrogen; sodium hydride; sodium hydrogencarbonate; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; 10% Pt/activated carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 4769-97-5
4-nitro-1H-indoIe

: 1389326-61-7
(E)-tert-butyl 1-(3-(4-chlorophenyl)-1-cyanopent-1-en-3-yl)-1H-indol-4-ylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

1.2: 3 h / 0 °C

2.1: hydrogen / 10% Pt/activated carbon / ethyl acetate / 3 h / Inert atmosphere

3.1: sodium hydrogencarbonate / 1,4-dioxane; water

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

4.2: 2 h / 0 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C

6.1: Dess-Martin periodane / dichloromethane / 2 h / 0 °C

7.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 2 h / 20 °C

With lithium aluminium tetrahydride; hydrogen; sodium hydride; sodium hydrogencarbonate; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; 10% Pt/activated carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;