4-(5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

Base Information

Chemical Name:4-(5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt
CAS No.:1430564-26-3
Molecular Formula:C₂HF₃O₂*C₂₈H₃₀N₄O₄
Molecular Weight:600.595
Hs Code.:

Synonyms:4-(5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

Suppliers and Price of 4-(5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

There total 7 articles about 4-(5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₇H₄₆N₄O₆

: 76-05-1
trifluoroacetic acid

: 1430564-26-3
4-(5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

Guidance literature:: for 2h;

Reference yield:

: 1109230-24-1
methyl 2-(2-bromophenyl)ethylcarbamate

: 1430564-26-3
4-(5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid; sulfuric acid / 0 - 20 °C

2: sodium hydroxide / ethanol; 1,4-dioxane / 0.5 h / 150 °C / Microwave irradiation

3: sodium hydroxide / 1,4-dioxane / 2 h

4: trichlorophosphate; pyridine / 2 h / -15 °C

5: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; 1,4-dioxane / 0.33 h / 130 °C / Inert atmosphere; Microwave irradiation

6: 2 h

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; potassium carbonate; acetic acid; sodium hydroxide; trichlorophosphate; In 1,4-dioxane; ethanol;

Reference yield:

: 65185-58-2
2-(2-bromophenyl)ethanamine

: 1430564-26-3
4-(5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / dichloromethane / 1 h / 0 °C

2: acetic acid; sulfuric acid / 0 - 20 °C

3: sodium hydroxide / ethanol; 1,4-dioxane / 0.5 h / 150 °C / Microwave irradiation

4: sodium hydroxide / 1,4-dioxane / 2 h

5: trichlorophosphate; pyridine / 2 h / -15 °C

6: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; 1,4-dioxane / 0.33 h / 130 °C / Inert atmosphere; Microwave irradiation

7: 2 h

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; potassium carbonate; acetic acid; sodium hydroxide; trichlorophosphate; In 1,4-dioxane; ethanol; dichloromethane;