[1-(4-Methoxy-phenyl)-2-oxo-4-((E)-styryl)-azetidin-3-yl]-thioacetic acid S-ethyl ester

Base Information

• Chemical Name: [1-(4-Methoxy-phenyl)-2-oxo-4-((E)-styryl)-azetidin-3-yl]-thioacetic acid S-ethyl ester
• CAS No.: 112634-04-5
• Molecular Formula: C₂₂H₂₃NO₃S
• Molecular Weight: 381.496
• Mol file: 112634-04-5.mol

Synonyms:[1-(4-Methoxy-phenyl)-2-oxo-4-((E)-styryl)-azetidin-3-yl]-thioacetic acid S-ethyl ester

Chemical Property of [1-(4-Methoxy-phenyl)-2-oxo-4-((E)-styryl)-azetidin-3-yl]-thioacetic acid S-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-(4-Methoxy-phenyl)-2-oxo-4-((E)-styryl)-azetidin-3-yl]-thioacetic acid S-ethyl ester

There total 7 articles about [1-(4-Methoxy-phenyl)-2-oxo-4-((E)-styryl)-azetidin-3-yl]-thioacetic acid S-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(3S,4R)-3-(2,2-Bis-ethylsulfanyl-vinyl)-1-(4-methoxy-phenyl)-4-((E)-styryl)-azetidin-2-one (112634-01-2,112710-45-9) → [1-(4-Methoxy-phenyl)-2-oxo-4-((E)-styryl)-azetidin-3-yl]-thioacetic acid S-ethyl ester (112634-04-5)

Guidance literature:

With trifluoroacetic acid; In ethanol; water; at 40 ℃; for 72h;

Reference yield:

(E)-3-phenylpropenal (14371-10-9) → [1-(4-Methoxy-phenyl)-2-oxo-4-((E)-styryl)-azetidin-3-yl]-thioacetic acid S-ethyl ester (112634-04-5)

Guidance literature:

Multi-step reaction with 3 steps

2: 52 percent / cyanuric chloride, triethylamine / CH₂Cl₂ / 1.) -40 deg C, 4 h, 2.) -40 to -18 deg C, overnight

3: 61 percent / trifluoroacetic acid / ethanol; H₂O / 72 h / 40 °C

With 1,3,5-trichloro-2,4,6-triazine; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; water;

Reference yield:

(E)-4-methoxy-N-((E)-3-phenylallylidene)aniline (88315-63-3) → [1-(4-Methoxy-phenyl)-2-oxo-4-((E)-styryl)-azetidin-3-yl]-thioacetic acid S-ethyl ester (112634-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / cyanuric chloride, triethylamine / CH₂Cl₂ / 1.) -40 deg C, 4 h, 2.) -40 to -18 deg C, overnight

2: 61 percent / trifluoroacetic acid / ethanol; H₂O / 72 h / 40 °C

With 1,3,5-trichloro-2,4,6-triazine; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; water;

upstream raw materials:

(3S,4R)-3-(2,2-Bis-ethylsulfanyl-vinyl)-1-(4-methoxy-phenyl)-4-((E)-styryl)-azetidin-2-one

(E)-3-phenylpropenal

(E)-4-methoxy-N-((E)-3-phenylallylidene)aniline

4-methoxy-aniline

Downstream raw materials:

[2-Oxo-4-((E)-styryl)-azetidin-3-yl]-thioacetic acid S-ethyl ester

N-Benzyl-2-[2-oxo-4-((E)-styryl)-azetidin-3-yl]-acetamide

Potassium; 3-(benzylcarbamoyl-methyl)-2-oxo-4-((E)-styryl)-azetidine-1-sulfonate

Potassium; 2-oxo-4-((E)-styryl)-3-{[(thiophen-2-ylmethyl)-carbamoyl]-methyl}-azetidine-1-sulfonate

Refernces