ethyl {3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-3-oxetanyl}acetate

Base Information

Chemical Name:ethyl {3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-3-oxetanyl}acetate
CAS No.:1312009-01-0
Molecular Formula:C₂₅H₂₅ClN₄O₅
Molecular Weight:496.95
Hs Code.:

Synonyms:ethyl {3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-3-oxetanyl}acetate

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Chemical Property of ethyl {3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-3-oxetanyl}acetate

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Technology Process of ethyl {3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-3-oxetanyl}acetate

There total 13 articles about ethyl {3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-3-oxetanyl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 922500-91-2
ethyl 2-(oxetan-3-ylidene)acetate

: 1312008-98-2
4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazole

: 1312009-01-0
ethyl {3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-3-oxetanyl}acetate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 - 80 ℃; Inert atmosphere;

Reference yield:

: 3964-57-6
methyl 4-hydroxy-3-chlorobenzoate

: 1312009-01-0
ethyl {3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-3-oxetanyl}acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

2.1: sodium hydroxide / methanol / 20 °C

2.2: pH 1 - 2 / Acidic conditions

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

4.1: triethylamine / acetonitrile / 0 °C / Inert atmosphere; Reflux

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 - 80 °C / Inert atmosphere

With oxalyl dichloride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 1312009-01-0
ethyl {3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-3-oxetanyl}acetate

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

2: triethylamine / acetonitrile / 0 °C / Inert atmosphere; Reflux

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 - 80 °C / Inert atmosphere

With oxalyl dichloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; In dichloromethane; acetonitrile;