(Z)-3-Methyl-4-oxo-2-((3S,4R)-2-oxo-3-phenylacetylamino-4-p-tolyldisulfanyl-azetidin-1-yl)-but-2-enoic acid benzhydryl ester

Base Information

Chemical Name:(Z)-3-Methyl-4-oxo-2-((3S,4R)-2-oxo-3-phenylacetylamino-4-p-tolyldisulfanyl-azetidin-1-yl)-but-2-enoic acid benzhydryl ester
CAS No.:76172-99-1
Molecular Formula:C₃₆H₃₂N₂O₅S₂
Molecular Weight:636.792
Hs Code.:

Synonyms:(Z)-3-Methyl-4-oxo-2-((3S,4R)-2-oxo-3-phenylacetylamino-4-p-tolyldisulfanyl-azetidin-1-yl)-but-2-enoic acid benzhydryl ester

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Chemical Property of (Z)-3-Methyl-4-oxo-2-((3S,4R)-2-oxo-3-phenylacetylamino-4-p-tolyldisulfanyl-azetidin-1-yl)-but-2-enoic acid benzhydryl ester

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Technology Process of (Z)-3-Methyl-4-oxo-2-((3S,4R)-2-oxo-3-phenylacetylamino-4-p-tolyldisulfanyl-azetidin-1-yl)-but-2-enoic acid benzhydryl ester

There total 1 articles about (Z)-3-Methyl-4-oxo-2-((3S,4R)-2-oxo-3-phenylacetylamino-4-p-tolyldisulfanyl-azetidin-1-yl)-but-2-enoic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 933-00-6
p-methylbenzenesulfenyl chloride

: 76172-98-0
2α-methoxy-3-cephem

: 76172-99-1
(Z)-3-Methyl-4-oxo-2-((3S,4R)-2-oxo-3-phenylacetylamino-4-p-tolyldisulfanyl-azetidin-1-yl)-but-2-enoic acid benzhydryl ester

Guidance literature:: In dichloromethane; at 0 ℃; for 30h;
DOI:10.1021/jo00317a043

Reference yield:

: 76172-99-1
(Z)-3-Methyl-4-oxo-2-((3S,4R)-2-oxo-3-phenylacetylamino-4-p-tolyldisulfanyl-azetidin-1-yl)-but-2-enoic acid benzhydryl ester

: 76173-03-0
7β-(phenylacetamido)-7α-methoxy-3-methyl-1-oxadethia-3-cephem-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium cyanoborohydride

2: 49 percent / mercuric trifluoroacetate

3: 88 percent / tert-butyl hypochlorite / tetrahydrofuran / 0.5 h / -70 °C

4: 84 percent / trifluoroacetic acid / various solvent(s) / 0.2 h / 0 °C / solvent: anisole

With tert-butylhypochlorite; mercury(II) trifluoroacetate; sodium cyanoborohydride; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1021/jo00317a043

Reference yield:

: 76172-99-1
(Z)-3-Methyl-4-oxo-2-((3S,4R)-2-oxo-3-phenylacetylamino-4-p-tolyldisulfanyl-azetidin-1-yl)-but-2-enoic acid benzhydryl ester

: 76173-02-9
diphenylmethyl 7β-(phenylacetamido)-7α-methoxy-3-methyl-1-oxadethia-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium cyanoborohydride

2: 49 percent / mercuric trifluoroacetate

3: 88 percent / tert-butyl hypochlorite / tetrahydrofuran / 0.5 h / -70 °C

With tert-butylhypochlorite; mercury(II) trifluoroacetate; sodium cyanoborohydride; In tetrahydrofuran;
DOI:10.1021/jo00317a043