Technology Process of methyl 8-cyclohexyl-5-((isopropylsulfonyl)carbamoyl)-11-methoxy-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylate
There total 9 articles about methyl 8-cyclohexyl-5-((isopropylsulfonyl)carbamoyl)-11-methoxy-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
trimethylsulfoxonium iodide;
With
sodium hydride;
In
dimethyl sulfoxide;
for 0.75h;
methyl 13-cyclohexyl-10-((isopropylsulfonyl)carbamoyl)-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylate;
In
dimethyl sulfoxide;
for 1h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; chloroform / 2.5 h / 0 - 5 °C
2.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 - 3 h / 90 °C / Heating / reflux
2.2: 1 h / 0 - 20 °C
3.1: silver carbonate / tetrahydrofuran; dichloromethane / 0 - 20 °C / Molecular sieve
4.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium(0) / ethanol; water; toluene / 0.25 h
4.2: 4 h / 85 °C
5.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C
6.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2.5 h / 20 °C
7.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 60 °C
7.2: 0.17 h
7.3: 20 °C
8.1: sodium hydride / dimethyl sulfoxide / 0.75 h
8.2: 1 h
With
lithium hydroxide; pyridinium hydrobromide perbromide; water; sodium hydride; sodium carbonate; caesium carbonate; 1,1'-carbonyldiimidazole; silver carbonate; trifluoroacetic acid; lithium chloride;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 - 3 h / 90 °C / Heating / reflux
1.2: 1 h / 0 - 20 °C
2.1: silver carbonate / tetrahydrofuran; dichloromethane / 0 - 20 °C / Molecular sieve
3.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium(0) / ethanol; water; toluene / 0.25 h
3.2: 4 h / 85 °C
4.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C
5.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2.5 h / 20 °C
6.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 60 °C
6.2: 0.17 h
6.3: 20 °C
7.1: sodium hydride / dimethyl sulfoxide / 0.75 h
7.2: 1 h
With
lithium hydroxide; water; sodium hydride; sodium carbonate; caesium carbonate; 1,1'-carbonyldiimidazole; silver carbonate; trifluoroacetic acid; lithium chloride;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;