1-azido-4--2-butanone ethylene ketal

Base Information

• Chemical Name: 1-azido-4--2-butanone ethylene ketal
• CAS No.: 78520-74-8
• Molecular Formula: C₁₄H₁₇N₃O₅
• Molecular Weight: 307.306
• Mol file: 78520-74-8.mol

Synonyms:1-azido-4--2-butanone ethylene ketal

Chemical Property of 1-azido-4--2-butanone ethylene ketal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-azido-4--2-butanone ethylene ketal

There total 2 articles about 1-azido-4--2-butanone ethylene ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

ethylene glycol (107-21-1) + 1-azido-4--2-butanone (78520-73-7) → 1-azido-4--2-butanone ethylene ketal (78520-74-8)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 6h; Heating;

DOI:10.1021/jm00141a010

Reference yield:

1-bromo-4-2-butanone (72155-10-3) → 1-azido-4--2-butanone ethylene ketal (78520-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / sodium azide, potassium iodide / acetone / 2 h

2: 82 percent / p-toluenesulfonic acid monohydrate / benzene / 6 h / Heating

With sodium azide; toluene-4-sulfonic acid; potassium iodide; In acetone; benzene;

DOI:10.1021/jm00141a010

Reference yield: 93.5%

1-azido-4--2-butanone ethylene ketal (78520-74-8) → 1-azido-4-(p-carboxyphenoxy)-2-butanone ethylene ketal (78520-75-9)

Guidance literature:

With sodium hydroxide; In acetonitrile; for 18h; Ambient temperature;

DOI:10.1021/jm00141a010

upstream raw materials:

ethylene glycol

1-azido-4--2-butanone

1-bromo-4-2-butanone

Downstream raw materials:

1-azido-4-(p-carboxyphenoxy)-2-butanone ethylene ketal

diethyl N--L-glutamate ketal

11-oxahomofolic acid

4-amino-4-deoxy-11-oxahomoaminopterin