2-isopropyl-7-phenyl-5-(trifluoromethyl) pyrido[2,3-d]pyrimidin-4(3H)-one

Base Information

Chemical Name:2-isopropyl-7-phenyl-5-(trifluoromethyl) pyrido[2,3-d]pyrimidin-4(3H)-one
CAS No.:1314534-91-2
Molecular Formula:C₁₇H₁₄F₃N₃O
Molecular Weight:333.313
Hs Code.:

Synonyms:2-isopropyl-7-phenyl-5-(trifluoromethyl) pyrido[2,3-d]pyrimidin-4(3H)-one

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Chemical Property of 2-isopropyl-7-phenyl-5-(trifluoromethyl) pyrido[2,3-d]pyrimidin-4(3H)-one

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Technology Process of 2-isopropyl-7-phenyl-5-(trifluoromethyl) pyrido[2,3-d]pyrimidin-4(3H)-one

There total 1 articles about 2-isopropyl-7-phenyl-5-(trifluoromethyl) pyrido[2,3-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 114085-00-6
2-amino-3-cyano-4-trifluoro-methyl-6-phenyl-pyridine

: 79-31-2
isobutyric Acid

: 1314534-91-2
2-isopropyl-7-phenyl-5-(trifluoromethyl) pyrido[2,3-d]pyrimidin-4(3H)-one

Guidance literature:: With sulfuric acid; at 120 - 130 ℃;
DOI:10.1016/j.ejmech.2011.05.011

Reference yield: 71.4%

: 1314534-91-2
2-isopropyl-7-phenyl-5-(trifluoromethyl) pyrido[2,3-d]pyrimidin-4(3H)-one

: 106-96-7
propargyl bromide

: 1314535-07-3
2-isopropyl-7-phenyl-4-(prop-2-ynyloxy)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine

: 1314534-97-8
2-isopropyl-7-phenyl-3-(prop-2-ynyl)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine-4(3H)one

Guidance literature:: With potassium carbonate; potassium iodide; In acetone; at 60 ℃; regioselective reaction;
DOI:10.1016/j.ejmech.2011.05.011

Reference yield:

: 1314534-91-2
2-isopropyl-7-phenyl-5-(trifluoromethyl) pyrido[2,3-d]pyrimidin-4(3H)-one

: 1314535-19-7
3-((1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)-1H-1,2,3-triazol-4-yl)methyl)-2-isopropyl-7-phenyl-5-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / acetone / 60 °C

2: copper(l) iodide / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With copper(l) iodide; potassium carbonate; potassium iodide; In tetrahydrofuran; acetone;
DOI:10.1016/j.ejmech.2011.05.011