1456-72-0

Basic information

• Product Name: 2-methyl-5-phenyl-1,3,4-thiadiazole
• Synonyms: 1,3,4-thiadiazole, 2-methyl-5-phenyl-; 2-Methyl-5-phenyl-1,3,4-thiadiazole
• CAS NO: 1456-72-0
• Molecular Formula: C₉H₈N₂S
• Molecular Weight: 176.2382
• Mol File: 1456-72-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 309.6°C at 760 mmHg
• Flash Point: 139.6°C
• Density: 1.199g/cm³
• Vapor Pressure: 0.00115mmHg at 25°C
• Refractive Index: 1.599
• CAS DataBase Reference: 2-methyl-5-phenyl-1,3,4-thiadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-5-phenyl-1,3,4-thiadiazole(1456-72-0)
• EPA Substance Registry System: 2-methyl-5-phenyl-1,3,4-thiadiazole(1456-72-0)

Safety Data

• Hazardous Substances Data: 1456-72-0(Hazardous Substances Data)

Upstream product

• 76689-65-1 2-phenyl-5,5-dimethyl-1,3,4-thiadiazol-2-ine 
• 20605-40-7 thiobenzoylhydrazine 
• 62-55-5 thioacetamide 
• 127-19-5 N,N-dimethyl acetamide 
• 1148055-45-1 [5-hydroxy-3-methyl-5-(trifluoromethyl)-4,5-dihydro-1Н-pyrazol-1-yl](phenyl)thioketone 
• 1258934-32-5 2-methyl-5-(2-methylaziridin-1-ylsulfonyl)-1,3,4-thiadiazole 
• 591-51-5 phenyllithium 
• 942-91-6 Carboxymethyl dithiobenzoate 
• 80403-41-4 Acetic acid [1-cyano-1-phenyl-meth-(Z)-ylidene]-hydrazide 
• 32252-82-7 1-chloro-1,4-diphenyl-2,3-diazabutadiene 
• 88222-76-8 2-(2-Methyl-5-phenyl-2,3-dihydro-[1,3,4]thiadiazol-2-yl)-1-phenyl-ethanone 
• 89983-82-4 1-thiobenzoyl-3-acetylacetamidrazone 
• 83342-10-3 2-Methyl-5-phenyl-2,3-dihydro-[1,3,4]thiadiazole 
• 90017-11-1 C₁₀H₈ClN₃ 

Downstream Products

• 85730-46-7 2-(5-phenyl-1,3,4-thiadiazol-2-yl)acetic acid 
• 81385-28-6 2-(2-Dimethylaminovinyl)-5-phenyl-1,3,4-thiadiazol 
• 121564-77-0 2-Bromomethyl-5-phenyl-[1,3,4]thiadiazole 
• 121564-78-1 2-Dibromomethyl-5-phenyl-[1,3,4]thiadiazole 
• 111297-82-6 phenyl-[1,3,4]thiadiazole-2-carbaldehyde-[N-(4-dimethylamino-phenyl)-oxime ] 
• 103028-60-0 phenyl-[1,3,4]thiadiazole-2-carboxylic acid 
• 4291-14-9 phenyl-1,3,4-thiadiazole 
• 85730-50-3 (5-Phenyl-[1,3,4]thiadiazol-2-yl)-(2,2,2-trichloro-ethoxycarbonylamino)-acetic acid ethyl ester 
• 85730-58-1 (5-Phenyl-[1,3,4]thiadiazol-2-ylmethyl)-carbamic acid 2,2,2-trichloro-ethyl ester 
• 85730-48-9 ethyl α-oximino-2-phenyl-1,3,4-thiadiazol-5-ylacetate 
• 85730-49-0 ethyl α-amino-2-phenyl-1,3,4-thiadiazol-5-ylacetate 
• 18070-82-1 2-ethoxycarbonylmethyl-5-phenyl-1,3,4-thiadiazole 
• 85730-57-0 C-(5-Phenyl-[1,3,4]thiadiazol-2-yl)-methylamine 
• 121564-79-2 2-Azidomethyl-5-phenyl-[1,3,4]thiadiazole 

Relevant articles and documents

Preparation method of 1, 3, 4-thiadiazole compound and compound prepared by preparation method

The invention belongs to the field of medicinal chemistry. Specifically, the invention discloses a preparation method of a 1, 3, 4-thiadiazole compound and the compound prepared by using the preparation method. According to the method, the 1, 3, 4-thiadia

A KHSO4 promoted tandem synthesis of 1,3,4-thiadiazoles from thiohydrazides and DMF derivatives

An efficient, simple and environmentally benign method for the construction of 1,3,4-thiadiazole skeletons via the tandem coupling and cyclization of thiohydrazides with DMF derivatives in the presence of KHSO4 has been reported. This method re

Ring opening of pymisyl-protected aziridines with organocuprates

The pyrimidine-2-sulfonyl (pymisyl) group is introduced as a new protecting group that can be used to activate aziridines towards ring opening. It is readily introduced and removed under mild conditions. Regioselective ring opening of pymisyl-protected 2-methyl-aziridine with organocuprates gives the corresponding sulfonamides in high yields, and the pymisyl group can subsequently be removed upon treatment with a thiolate. The versatility of this new nitrogen protecting group is illustrated with a new synthesis of Selegiline, a monoamine oxidase-B inhibitor marketed for the treatment of Parkinson's disease. Easy on'easy off: The pymisyl group is introduced as a new protecting group for the activation of aziridines towards ring opening with organocuprates (see scheme). It is readily removed under very mild conditions with thiolates. The versatility of the approach is illustrated in a new synthesis of Selegiline, a drug marketed for the treatment of Parkinson's disease.