N¹-(4-tert-butylphenyl)-N²-hydroxy-4-(3-chloropyridin-2-yl)-(R)-2-methylpiperazine-1-carboxamidine

Base Information

• Chemical Name: N¹-(4-tert-butylphenyl)-N²-hydroxy-4-(3-chloropyridin-2-yl)-(R)-2-methylpiperazine-1-carboxamidine
• CAS No.: 676609-11-3
• Molecular Formula: C₂₁H₂₈ClN₅O
• Molecular Weight: 401.939

Synonyms:N¹-(4-tert-butylphenyl)-N²-hydroxy-4-(3-chloropyridin-2-yl)-(R)-2-methylpiperazine-1-carboxamidine

Chemical Property of N¹-(4-tert-butylphenyl)-N²-hydroxy-4-(3-chloropyridin-2-yl)-(R)-2-methylpiperazine-1-carboxamidine

Chemical Property:

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Technology Process of N¹-(4-tert-butylphenyl)-N²-hydroxy-4-(3-chloropyridin-2-yl)-(R)-2-methylpiperazine-1-carboxamidine

There total 5 articles about N¹-(4-tert-butylphenyl)-N²-hydroxy-4-(3-chloropyridin-2-yl)-(R)-2-methylpiperazine-1-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

C22H29ClN4S → N1-(4-tert-butylphenyl)-N2-hydroxy-4-(3-chloropyridin-2-yl)-(R)-2-methylpiperazine-1-carboxamidine (676609-11-3)

Guidance literature:

With hydroxylamine; In ethanol; at 80 ℃; for 2h;

Reference yield:

(2R)-methylpiperazine (75336-86-6) → N1-(4-tert-butylphenyl)-N2-hydroxy-4-(3-chloropyridin-2-yl)-(R)-2-methylpiperazine-1-carboxamidine (676609-11-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine / dimethyl sulfoxide / 24 h / 100 °C

2.1: dichloromethane / 5 h / 25 °C

3.1: DMF (N,N-dimethyl-formamide) / 12 h / 25 °C

3.2: 2 h

4.1: hydroxylamine / ethanol / 2 h / 80 °C

With hydroxylamine; triethylamine; In DMF (N,N-dimethyl-formamide); ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

(R)-1-(3-chloropyridin-2-yl)-3-methylpiperazine (393513-95-6) → N1-(4-tert-butylphenyl)-N2-hydroxy-4-(3-chloropyridin-2-yl)-(R)-2-methylpiperazine-1-carboxamidine (676609-11-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dichloromethane / 5 h / 25 °C

2.1: DMF (N,N-dimethyl-formamide) / 12 h / 25 °C

2.2: 2 h

3.1: hydroxylamine / ethanol / 2 h / 80 °C

With hydroxylamine; In DMF (N,N-dimethyl-formamide); ethanol; dichloromethane;

upstream raw materials:

2,3-dichloro-pyridine

C₂₁H₂₇ClN₄S

(2R)-methylpiperazine

(R)-1-(3-chloropyridin-2-yl)-3-methylpiperazine

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