(S)-2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester

Base Information

• Chemical Name: (S)-2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester
• CAS No.: 258354-22-2
• Molecular Formula: C₁₅H₂₁NO₃
• Molecular Weight: 263.337
• Mol file: 258354-22-2.mol

Synonyms:(S)-2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester

Chemical Property of (S)-2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester

There total 1 articles about (S)-2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Ala-OtBu (21691-50-9) + 4-methoxy-benzaldehyde (123-11-5) → (S)-2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester (258354-22-2)

Guidance literature:

With pyridine; In toluene; for 4h; Heating;

DOI:10.1016/S0040-4020(97)00060-4

Reference yield:

benzyl bromide (100-39-0) + (S)-2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester (258354-22-2) → (R)-2-amino-2-methyl-3-phenylpropanoic acid tert-butyl ester (147714-90-7) + (S)-α-methylphenylalanine tert-butyl ester

Guidance literature:

benzyl bromide; (S)-2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester; With potassium hydroxide; potassium carbonate; N-anthracenylmethyl dihydrocinchonidinium bromide; In toluene; at 20 ℃;

In tetrahydrofuran; water; acetic acid; at 20 ℃; for 24h;

DOI:10.1016/S0040-4039(99)01836-5

Reference yield:

(S)-2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester (258354-22-2) → (S)-2-((2S,3S)-3-Hydroxy-2-phenylsulfanyl-hexylamino)-propionic acid tert-butyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: 72 h / 0 °C

2: aq. NaHCO₃

3: AcOH / methanol

With sodium hydrogencarbonate; acetic acid; In methanol;

DOI:10.1016/S0040-4020(97)00060-4

upstream raw materials:

Ala-OtBu

4-methoxy-benzaldehyde

Downstream raw materials:

(R)-2-amino-2-methyl-3-phenylpropanoic acid tert-butyl ester