methyl 3-(benzoylamino)-2,5,6,7,8,9-hexahydro-8,8-dimethyl-2,5-dioxo-1H-pyrido<3,2-c>azepine-1-acetate

Base Information

• Chemical Name: methyl 3-(benzoylamino)-2,5,6,7,8,9-hexahydro-8,8-dimethyl-2,5-dioxo-1H-pyrido<3,2-c>azepine-1-acetate
• CAS No.: 128398-53-8
• Molecular Formula: C₂₁H₂₃N₃O₅
• Molecular Weight: 397.431

Synonyms:methyl 3-(benzoylamino)-2,5,6,7,8,9-hexahydro-8,8-dimethyl-2,5-dioxo-1H-pyrido<3,2-c>azepine-1-acetate

Chemical Property of methyl 3-(benzoylamino)-2,5,6,7,8,9-hexahydro-8,8-dimethyl-2,5-dioxo-1H-pyrido<3,2-c>azepine-1-acetate

Chemical Property:

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Technology Process of methyl 3-(benzoylamino)-2,5,6,7,8,9-hexahydro-8,8-dimethyl-2,5-dioxo-1H-pyrido<3,2-c>azepine-1-acetate

There total 2 articles about methyl 3-(benzoylamino)-2,5,6,7,8,9-hexahydro-8,8-dimethyl-2,5-dioxo-1H-pyrido<3,2-c>azepine-1-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methyl 3-(benzoylamino)-5,6,7,8-tetrahydro-7,7-dimethyl-2,5-dioxo-1(2H)-quinolineacetate (128398-48-1) → methyl 3-(benzoylamino)-2,5,6,7,8,9-hexahydro-8,8-dimethyl-2,5-dioxo-1H-pyrido<3,2-c>azepine-1-acetate (128398-53-8)

Guidance literature:

With sodium azide; sulfuric acid; In chloroform; 1.) 0 deg C, 1.5 h, 2.) RT, 2 h;

DOI:10.3987/COM-89-S8

Reference yield:

methanol (67-56-1) + N-<1-<(azidocarbonyl)methyl>-2,5,6,7,8,9-hexahydro-8,8-dimethyl-2,5-dioxo-1H-pyrido<3,2-c>azepin-3-yl>benzamide (156470-14-3) → methyl 3-(benzoylamino)-2,5,6,7,8,9-hexahydro-8,8-dimethyl-2,5-dioxo-1H-pyrido<3,2-c>azepine-1-acetate (128398-53-8) + methyl <<3-(benzoylamino)-2,5,6,7,8,9-hexahydro-8,8-dimethyl-2,5-dioxo-1H-pyrido<3,2-c>azepin-3-yl>methyl>carbamate (156470-15-4)

Guidance literature:

for 2.5h; Yield given. Yields of byproduct given; Heating;

Reference yield: 90.0%

methyl 3-(benzoylamino)-2,5,6,7,8,9-hexahydro-8,8-dimethyl-2,5-dioxo-1H-pyrido<3,2-c>azepine-1-acetate (128398-53-8) → N-<1-(carbazoylmethyl)-2,5,6,7,8,9-hexahydro-8,8-dimethyl-2,5-dioxo-1H-pyrido<3,2-c>azepin-3-yl>benzamide (156470-13-2)

Guidance literature:

With hydrazine hydrate; In ethanol; for 4h; Heating;

upstream raw materials:

methanol

N-<1-<(azidocarbonyl)methyl>-2,5,6,7,8,9-hexahydro-8,8-dimethyl-2,5-dioxo-1H-pyrido<3,2-c>azepin-3-yl>benzamide

methyl 3-(benzoylamino)-5,6,7,8-tetrahydro-7,7-dimethyl-2,5-dioxo-1(2H)-quinolineacetate

Downstream raw materials:

N-<1-(carbazoylmethyl)-2,5,6,7,8,9-hexahydro-8,8-dimethyl-2,5-dioxo-1H-pyrido<3,2-c>azepin-3-yl>benzamide

N-(8,8-Dimethyl-2,5-dioxo-2,5,6,7,8,9-hexahydro-1H-pyrido[3,2-c]azepin-3-yl)-benzamide

3-(benzoylamino)-2,5,6,7,8-hexahydro-8,8-dimethyl-2,5-dioxo-1H-pyrido<3,2-c>azepine-1-acetic acid

N-<2,5,6,7,8,9-hexahydro-1-(isocyanatomethyl)-8,8-dimethyl-2,5-dioxo-1H-pyrido<3,2-c>azepin-3-yl>benzamide

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