1-[bis(4-fluorophenyl)methyl]-4-[(2Z)-3-phenylprop-2-en-1-yl]piperazine

Base Information

Chemical Name:1-[bis(4-fluorophenyl)methyl]-4-[(2Z)-3-phenylprop-2-en-1-yl]piperazine
CAS No.:693765-11-6
Molecular Formula:C₂₆H₂₆F₂N₂
Molecular Weight:404.503
Hs Code.:

Synonyms:1-[bis(4-fluorophenyl)methyl]-4-[(2Z)-3-phenylprop-2-en-1-yl]piperazine

Suppliers and Price of 1-[bis(4-fluorophenyl)methyl]-4-[(2Z)-3-phenylprop-2-en-1-yl]piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(Z)-Flunarizine
25mg
$ 185.00

Total 6 raw suppliers

Chemical Property of 1-[bis(4-fluorophenyl)methyl]-4-[(2Z)-3-phenylprop-2-en-1-yl]piperazine

Chemical Property:

Boiling Point:511.3±50.0 °C(Predicted)
Density:1.170±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

(Z)-Flunarizine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (Z)-Flunarizine is Z-isomer of Flunarizine(F455200, Dihydrochloride), which is a calcium channel blocker. Flunarizine is a fluorinated derivative of Cinnarizine and a vasodilator (cerebral and peripheral). EP Impurity C

Technology Process of 1-[bis(4-fluorophenyl)methyl]-4-[(2Z)-3-phenylprop-2-en-1-yl]piperazine

There total 3 articles about 1-[bis(4-fluorophenyl)methyl]-4-[(2Z)-3-phenylprop-2-en-1-yl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1-[bis(4-fluorophenyl)methyl]-4-[(2Z)-3-chloroprop-2-en-1-yl]piperazine

: 100-59-4
phenylmagnesium chloride

: 693765-11-6
1-[bis(4-fluorophenyl)methyl]-4-[(2Z)-3-phenylprop-2-en-1-yl]piperazine

: 52468-60-7
flunarizine

Guidance literature:: With 1-methyl-pyrrolidin-2-one; iron(III)-acetylacetonate; In tetrahydrofuran; at 0 - 20 ℃; for 1h; stereoselective reaction; Inert atmosphere;
DOI:10.1134/S107036321608034X

Reference yield: 69.4%

: 1522375-87-6
1-(4,4’-difluorophenylmethyl)-4-(2-acetaldehyde)piperazine

: 1100-88-5
benzyltriphenylphosphonium chloride

: 693765-11-6
1-[bis(4-fluorophenyl)methyl]-4-[(2Z)-3-phenylprop-2-en-1-yl]piperazine

: 52468-60-7
flunarizine

Guidance literature:: With potassium tert-butylate; In dichloromethane; at 5 ℃; stereoselective reaction; Inert atmosphere;
DOI:10.1080/00397911.2013.826808

Reference yield:

: 1522375-84-3
1-[bis(4-fluorophenyl)methyl]-4-(2,2-dimethoxyethyl)piperazine

: 693765-11-6
1-[bis(4-fluorophenyl)methyl]-4-[(2Z)-3-phenylprop-2-en-1-yl]piperazine

: 52468-60-7
flunarizine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide; water / 20 °C

2: potassium tert-butylate / dichloromethane / 5 °C / Inert atmosphere

With potassium tert-butylate; water; hydrogen bromide; In dichloromethane; 2: |Wittig Olefination;
DOI:10.1080/00397911.2013.826808