N-cyclopropyl-4-{6-[1-(3-fluoro-4-methoxyphenyl)vinyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

Base Information

Chemical Name:N-cyclopropyl-4-{6-[1-(3-fluoro-4-methoxyphenyl)vinyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide
CAS No.:1401450-93-8
Molecular Formula:C₃₀H₂₈F₄N₄O₂
Molecular Weight:552.572
Hs Code.:

Synonyms:N-cyclopropyl-4-{6-[1-(3-fluoro-4-methoxyphenyl)vinyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

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Chemical Property of N-cyclopropyl-4-{6-[1-(3-fluoro-4-methoxyphenyl)vinyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

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Technology Process of N-cyclopropyl-4-{6-[1-(3-fluoro-4-methoxyphenyl)vinyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

There total 9 articles about N-cyclopropyl-4-{6-[1-(3-fluoro-4-methoxyphenyl)vinyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1401450-86-9
N-cyclopropyl-4-{6-(3-fluoro-4-methoxybenzoyl)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

: 1779-49-3
Methyltriphenylphosphonium bromide

: 1401450-93-8
N-cyclopropyl-4-{6-[1-(3-fluoro-4-methoxyphenyl)vinyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

Guidance literature:: Methyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; hexane; at 23 ℃; for 0.5h;

N-cyclopropyl-4-{6-(3-fluoro-4-methoxybenzoyl)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide; In tetrahydrofuran; hexane; at 23 ℃;

Reference yield:

: 62554-90-9
4-bromo-2,6-dinitroaniline

: 1401450-93-8
N-cyclopropyl-4-{6-[1-(3-fluoro-4-methoxyphenyl)vinyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride; tin(II) chloride dihdyrate / water / -20 - 20 °C

1.2: pH 10

2.1: hydrogenchloride / 20 °C / Reflux

2.2: pH 8

3.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 23 °C

3.2: 3 °C

4.1: pyridine N-oxide; pyridine; copper diacetate / dichloromethane / 60 h / 23 °C

5.1: N-ethyl-N,N-diisopropylamine; palladium diacetate; catacxium A / toluene / 100 °C / 10501.1 Torr

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 23 °C

7.1: dmap; HATU / N,N-dimethyl-formamide / 23 °C

8.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / 23 °C

8.2: 23 °C

With pyridine; pyridine N-oxide; hydrogenchloride; dmap; n-butyllithium; tin(II) chloride dihdyrate; water; copper diacetate; palladium diacetate; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; catacxium A; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1121586-23-9
5-bromobenzene-1,2,3-triamine

: 1401450-93-8
N-cyclopropyl-4-{6-[1-(3-fluoro-4-methoxyphenyl)vinyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / 20 °C / Reflux

1.2: pH 8

2.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 23 °C

2.2: 3 °C

3.1: pyridine N-oxide; pyridine; copper diacetate / dichloromethane / 60 h / 23 °C

4.1: N-ethyl-N,N-diisopropylamine; palladium diacetate; catacxium A / toluene / 100 °C / 10501.1 Torr

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 23 °C

6.1: dmap; HATU / N,N-dimethyl-formamide / 23 °C

7.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / 23 °C

7.2: 23 °C

With pyridine; pyridine N-oxide; hydrogenchloride; dmap; n-butyllithium; water; copper diacetate; palladium diacetate; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; catacxium A; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;