(3aS,4S,6R,6aS)-4-methoxy-2,2-dimethyl-6-vinyltetrahydrofuro[3,4-d][1,3]dioxole

Base Information

• Chemical Name: (3aS,4S,6R,6aS)-4-methoxy-2,2-dimethyl-6-vinyltetrahydrofuro[3,4-d][1,3]dioxole
• CAS No.: 57783-59-2
• Molecular Formula: C₁₀H₁₆O₄
• Molecular Weight: 200.235
• Mol file: 57783-59-2.mol

Synonyms:(3aS,4S,6R,6aS)-4-methoxy-2,2-dimethyl-6-vinyltetrahydrofuro[3,4-d][1,3]dioxole

Chemical Property of (3aS,4S,6R,6aS)-4-methoxy-2,2-dimethyl-6-vinyltetrahydrofuro[3,4-d][1,3]dioxole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (3aS,4S,6R,6aS)-4-methoxy-2,2-dimethyl-6-vinyltetrahydrofuro[3,4-d][1,3]dioxole

There total 7 articles about (3aS,4S,6R,6aS)-4-methoxy-2,2-dimethyl-6-vinyltetrahydrofuro[3,4-d][1,3]dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + (3aS,4S,6R,6aS)-2,2-dimethyl-6-vinyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (73111-64-5) → (3aS,4S,6R,6aS)-4-methoxy-2,2-dimethyl-6-vinyltetrahydrofuro[3,4-d][1,3]dioxole (57783-59-2,828937-31-1)

Guidance literature:

With camphor-10-sulfonic acid; at 55 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b01602

Reference yield: 99.0%

(3aS,4S,6R,6aS)-2,2-dimethyl-6-vinyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (73111-64-5) + 2,2-dimethoxy-propane (77-76-9) → (3aS,4S,6R,6aS)-4-methoxy-2,2-dimethyl-6-vinyltetrahydrofuro[3,4-d][1,3]dioxole (57783-59-2,828937-31-1)

Guidance literature:

With camphor-10-sulfonic acid; In methanol; at 55 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.joc.8b00101

Reference yield: 96.0%

Methanesulfonic acid 2-methanesulfonyloxy-1-((3aS,4S,6S,6aS)-6-methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-ethyl ester → (3aS,4S,6R,6aS)-4-methoxy-2,2-dimethyl-6-vinyltetrahydrofuro[3,4-d][1,3]dioxole (57783-59-2,828937-31-1)

Guidance literature:

With copper; sodium iodide; zinc;

DOI:10.1016/S0008-6215(98)00323-1

upstream raw materials:

Methyl 1,2-O-isopropylidene-5,6-dimethanesulphonyl-α-D-glucofuranoside

methanol

(3aS,4S,6R,6aS)-2,2-dimethyl-6-vinyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol

methyl 6-deoxy-6-iodo-2,3-O-isopropylidene-α-D-mannopyranoside

Downstream raw materials:

3,4-diphenyl-furazan 2-oxide