(S)-methyl 3-(4-(2-((tert-butoxycarbonyl)amino)-3-(1H-indol-3-yl)propoxy)-3-methoxyphenyl)propanoate

Base Information

Chemical Name:(S)-methyl 3-(4-(2-((tert-butoxycarbonyl)amino)-3-(1H-indol-3-yl)propoxy)-3-methoxyphenyl)propanoate
CAS No.:1403949-80-3
Molecular Formula:C₂₇H₃₄N₂O₆
Molecular Weight:482.577
Hs Code.:

Synonyms:(S)-methyl 3-(4-(2-((tert-butoxycarbonyl)amino)-3-(1H-indol-3-yl)propoxy)-3-methoxyphenyl)propanoate

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Chemical Property of (S)-methyl 3-(4-(2-((tert-butoxycarbonyl)amino)-3-(1H-indol-3-yl)propoxy)-3-methoxyphenyl)propanoate

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Technology Process of (S)-methyl 3-(4-(2-((tert-butoxycarbonyl)amino)-3-(1H-indol-3-yl)propoxy)-3-methoxyphenyl)propanoate

There total 6 articles about (S)-methyl 3-(4-(2-((tert-butoxycarbonyl)amino)-3-(1H-indol-3-yl)propoxy)-3-methoxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 56024-44-3
methyl 3-(4-hydroxy-3-methoxyphenyl)propanoate

: 110659-38-6,143259-51-2,82689-19-8
N-t-butoxycarbonyl-tryptophanol

: 1403949-80-3
(S)-methyl 3-(4-(2-((tert-butoxycarbonyl)amino)-3-(1H-indol-3-yl)propoxy)-3-methoxyphenyl)propanoate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 4h;
DOI:10.1021/ml300366t

Reference yield:

: 1135-24-6,537-98-4
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

: 1403949-80-3
(S)-methyl 3-(4-(2-((tert-butoxycarbonyl)amino)-3-(1H-indol-3-yl)propoxy)-3-methoxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / 6 h / 80 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h

With palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; 3: |Mitsunobu Displacement;
DOI:10.1021/ml300366t

Reference yield:

: 2309-07-1
Methyl ferulate

: 1403949-80-3
(S)-methyl 3-(4-(2-((tert-butoxycarbonyl)amino)-3-(1H-indol-3-yl)propoxy)-3-methoxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h

With palladium 10% on activated carbon; hydrogen; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; 2: |Mitsunobu Displacement;
DOI:10.1021/ml300366t