trans-(R)-1-[6-benzenesulfonyl-1-(4-oxazol-5-yl-cyclohexyl)-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl]-ethanol

Base Information

Chemical Name:trans-(R)-1-[6-benzenesulfonyl-1-(4-oxazol-5-yl-cyclohexyl)-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl]-ethanol
CAS No.:1418199-81-1
Molecular Formula:C₂₅H₂₅N₅O₄S
Molecular Weight:491.571
Hs Code.:

Synonyms:trans-(R)-1-[6-benzenesulfonyl-1-(4-oxazol-5-yl-cyclohexyl)-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl]-ethanol

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Chemical Property of trans-(R)-1-[6-benzenesulfonyl-1-(4-oxazol-5-yl-cyclohexyl)-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl]-ethanol

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Technology Process of trans-(R)-1-[6-benzenesulfonyl-1-(4-oxazol-5-yl-cyclohexyl)-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl]-ethanol

There total 5 articles about trans-(R)-1-[6-benzenesulfonyl-1-(4-oxazol-5-yl-cyclohexyl)-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 598-81-2
(R)-lactamide

: 1418199-80-0
trans-1-benzenesulfonyl-N*4*-(4-oxazol-5-yl-cyclohexyl)-1H-pyrrolo[2,3-b]pyridine-4,5-diamine

: 1418199-81-1
trans-(R)-1-[6-benzenesulfonyl-1-(4-oxazol-5-yl-cyclohexyl)-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl]-ethanol

Guidance literature:: (R)-lactamide; With triethyloxonium fluoroborate; In ethanol; at 20 ℃; for 2h;

trans-1-benzenesulfonyl-N*4*-(4-oxazol-5-yl-cyclohexyl)-1H-pyrrolo[2,3-b]pyridine-4,5-diamine; In ethanol; at 80 ℃; for 22h;

Reference yield:

: 181308-57-6
trans-(4-formyl-cyclohexyl)-carbamic acid tert-butyl ester

: 1418199-81-1
trans-(R)-1-[6-benzenesulfonyl-1-(4-oxazol-5-yl-cyclohexyl)-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl]-ethanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / 2 h / 65 °C

2.1: trifluoroacetic acid / dichloromethane / 0.67 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 3 h / 80 °C

4.1: ammonium chloride; iron / ethanol / 1.5 h / Reflux

5.1: triethyloxonium fluoroborate / ethanol / 2 h / 20 °C

5.2: 22 h / 80 °C

With triethyloxonium fluoroborate; iron; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; isopropyl alcohol;

Reference yield:

: 1418200-47-1
trans-(4-oxazol-5-yl-cyclohexyl)-carbamic acid tert-butyl ester

: 1418199-81-1
trans-(R)-1-[6-benzenesulfonyl-1-(4-oxazol-5-yl-cyclohexyl)-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl]-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 0.67 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 3 h / 80 °C

3.1: ammonium chloride; iron / ethanol / 1.5 h / Reflux

4.1: triethyloxonium fluoroborate / ethanol / 2 h / 20 °C

4.2: 22 h / 80 °C

With triethyloxonium fluoroborate; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; isopropyl alcohol;