methyl 7-methoxy-3-oxo-4-[3-(4-phenylpiperazine-1-yl)propyl]-3,4-dihydro-2H-1,5-benzoxathiepine-4-carboxylate

Base Information

• Chemical Name: methyl 7-methoxy-3-oxo-4-[3-(4-phenylpiperazine-1-yl)propyl]-3,4-dihydro-2H-1,5-benzoxathiepine-4-carboxylate
• CAS No.: 99013-77-1
• Molecular Formula: C₂₅H₃₀N₂O₅S
• Molecular Weight: 470.59

Synonyms:methyl 7-methoxy-3-oxo-4-[3-(4-phenylpiperazine-1-yl)propyl]-3,4-dihydro-2H-1,5-benzoxathiepine-4-carboxylate

Chemical Property of methyl 7-methoxy-3-oxo-4-[3-(4-phenylpiperazine-1-yl)propyl]-3,4-dihydro-2H-1,5-benzoxathiepine-4-carboxylate

Chemical Property:

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Technology Process of methyl 7-methoxy-3-oxo-4-[3-(4-phenylpiperazine-1-yl)propyl]-3,4-dihydro-2H-1,5-benzoxathiepine-4-carboxylate

There total 4 articles about methyl 7-methoxy-3-oxo-4-[3-(4-phenylpiperazine-1-yl)propyl]-3,4-dihydro-2H-1,5-benzoxathiepine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-phenyl-1-piperazine (92-54-6) + methyl 4-(3-chloropropyl)-7-methoxy-3-oxo-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylate (99203-94-8) → methyl 7-methoxy-3-oxo-4-[3-(4-phenylpiperazine-1-yl)propyl]-3,4-dihydro-2H-1,5-benzoxathiepine-4-carboxylate (99013-77-1)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 70 ℃; for 7h;

DOI:10.1248/cpb.35.1930

Reference yield: 31.0%

3-(4-phenyl-1-piperazinyl)propyl chloride (67980-67-0) + methyl 7-methoxy-3-oxo-3,4-dihydro-2H-1,5-benzoxathiepine-4-carboxylate (99013-55-5) → methyl 7-methoxy-3-oxo-4-[3-(4-phenylpiperazine-1-yl)propyl]-3,4-dihydro-2H-1,5-benzoxathiepine-4-carboxylate (99013-77-1)

Guidance literature:

With potassium carbonate; potassium iodide; In acetonitrile; for 4h; Heating;

DOI:10.1248/cpb.35.1930

Reference yield:

1-(3-chloropropyl)-4-phenylpiperazine (10599-17-4) + methyl 7-methoxy-3-oxo-3,4-dihydro-2H-1,5-benzoxathiepine-4-carboxylate (99013-55-5) → methyl 7-methoxy-3-oxo-4-[3-(4-phenylpiperazine-1-yl)propyl]-3,4-dihydro-2H-1,5-benzoxathiepine-4-carboxylate (99013-77-1)

Guidance literature:

With potassium iodide; potassium carbonate; In ethyl acetate; butanone;

upstream raw materials:

4-phenyl-1-piperazine

methyl 4-(3-chloropropyl)-7-methoxy-3-oxo-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylate

3-(4-phenyl-1-piperazinyl)propyl chloride

methyl 7-methoxy-3-oxo-3,4-dihydro-2H-1,5-benzoxathiepine-4-carboxylate

Downstream raw materials:

methyl cis-3-hydroxy-7-methoxy-4-<3-(4-phenyl-1-piperazinyl)propyl>-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylate (CV-5197) hydrochloride

methyl trans-3-hydroxy-7-methoxy-4-<3-(4-phenyl-1-piperazinyl)propyl>-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylate hydrochloride

cis-4-hydroxymethyl-7-methoxy-4-<3-(4-phenyl-1-piperazinyl)propyl>-3,4-dihydro-2H-1,5-benzoxathiepin-3-ol

cis-3-hydroxy-7-methoxy-4-<3-(4-phenyl-1-piperazinyl)propyl>-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylic acid

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