4-Aminopyridine-3-carbohydrazide

Base Information

• Chemical Name: 4-Aminopyridine-3-carbohydrazide
• CAS No.: 89533-20-0
• Molecular Formula: C₆H₈N₄O
• Molecular Weight: 152.156
• DSSTox Substance ID: DTXSID00542258
• Wikidata: Q82418859
• Mol file: 89533-20-0.mol

Synonyms:4-Aminonicotinohydrazide;89533-20-0;4-Aminopyridine-3-carbohydrazide;DTXSID00542258;EN300-2973120

Chemical Property of 4-Aminopyridine-3-carbohydrazide

Chemical Property:

• PKA: 11.58±0.10(Predicted)
• PSA: 98.25000
• Density: 1.352±0.06 g/cm3(Predicted)
• LogP: 0.47250
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 152.06981089
• Heavy Atom Count: 11
• Complexity: 150

Purity/Quality:

4-Aminonicotinohydrazide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CC(=C1N)C(=O)NN

Technology Process of 4-Aminopyridine-3-carbohydrazide

There total 4 articles about 4-Aminopyridine-3-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-3-ethoxycarbonylpyridine (16952-66-2) → 4-aminonicotinoyl hydrazide (89533-20-0)

Guidance literature:

With hydrazine hydrate; In ethanol; Reflux;

DOI:10.1016/j.bmc.2013.02.008

Reference yield:

4-aminonicotinic acid (7418-65-7) → 4-aminonicotinoyl hydrazide (89533-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid

2: hydrazine hydrate / ethanol / Reflux

With sulfuric acid; hydrazine hydrate; In ethanol;

DOI:10.1016/j.bmc.2013.02.008

Reference yield:

methyl 4-aminonicotinate (16135-36-7) → 4-aminonicotinoyl hydrazide (89533-20-0)

Guidance literature:

With hydrazine hydrate;

DOI:10.1021/jo50012a013

upstream raw materials:

methyl 4-aminonicotinate

4-amino-3-ethoxycarbonylpyridine

4-aminonicotinic acid

Downstream raw materials:

4-aminopyridine-3-carboxamide