16135-36-7

Basic information

• Product Name: Methyl 4-aminopyridine-3-carboxylate
• Synonyms: Methyl 4-aminopyridine-3-carboxylate, 4-Aminonicotinic acid methyl ester;RARECHEM AL BF 1386;4-amino-3-pyridinecarboxylic acid methyl ester;4-AMINOPYRIDINE-3-CARBOXYLIC ACID METHYL ESTER;4-AMINONICOTINIC ACID METHYL ESTER;methyl 4-aminopyridine-3-carboxylate;METHYL-4-AMINONICOTINATE;4-Amino-nicotinic acid methyl ester ,97%
• CAS NO: 16135-36-7
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15
• Product Categories: pharmacetical;Pyridine series;Esters;Pyridines;Pyridine
• Mol File: 16135-36-7.mol
• Article Data: 15

Chemical Properties

• Melting Point: 172-174℃
• Boiling Point: 288.7 °C at 760 mmHg
• Flash Point: 128.4 °C
• Appearance: /
• Density: 1.238 g/cm³
• Vapor Pressure: 0.0023mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 7.04±0.12(Predicted)
• CAS DataBase Reference: Methyl 4-aminopyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-aminopyridine-3-carboxylate(16135-36-7)
• EPA Substance Registry System: Methyl 4-aminopyridine-3-carboxylate(16135-36-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-37
• RIDADR: UN2811
• Hazardous Substances Data: 16135-36-7(Hazardous Substances Data)

Usage

Chemical Properties

Off-white solid

InChI:InChI=1/C7H8N2O2/c1-11-7(10)5-4-9-3-2-6(5)8/h2-4H,1H3,(H2,8,9)

Upstream product

• 10177-29-4 4-chloronicotinic acid 
• 4664-08-8 cinchomeronic anhydride 
• 1356116-53-4 methyl 4-((methoxycarbonyl)amino)nicotinate 
• 67-56-1 methanol 
• 280115-84-6 4-tert-butoxycarbonylamino-nicotinic acid methyl ester 
• 104915-66-4 N-(3-methylpyridin-4-yl)acetamide 
• 1074-98-2 3-methyl-4-nitropyridine N-oxide 
• 1003-73-2 3-picoline-N-oxide 
• 105-45-3 acetoacetic acid methyl ester 
• 17758-33-7 3-methyl-5-nitro-4(3H)-pyrimidinone 
• 7418-65-7 4-aminonicotinic acid 
• 98550-10-8 methyl 4-nitronicotinate 1-oxide 
• 60770-86-7 4-(acetylamino)nicotinic acid 
• 1078-05-3 4-nitro-3-carboxypyridine 1-oxide 

Downstream Products

• 138116-34-4 4-amino-3-hydroxymethylpyridine 
• 674793-74-9 C₁₉H₁₇ClFN₅O₂ 
• 674793-50-1 C₁₈H₁₄ClFN₄O₃ 

Relevant articles and documents

Facile synthesis of functionalized 4-aminopyridines

The title compounds are readily available by ring transformation of nitropyrimidinone with active methylene compounds in the presence of ammonium acetate.

High-yield synthesis method of methyl 4-aminonicotinate

The invention discloses a high-yield synthesis method of methyl 4-aminonicotinate, which comprises the following steps: by taking 3, 4-dipicolinic acid as a raw material, carrying out intramolecular dehydration substitution, ammonia ammonification, improved NBS Hofmann rearrangement and hydrolysis to obtain the methyl 4-aminonicotinate. The synthesis method disclosed by the invention is simpler to operate, mild in reaction condition and higher in total yield, and has an extremely high application value.

Novel Aryl-Modified Benzoylamino-N-(5,6-dimethoxy-1H-benzoimidazol-2-yl)-heteroamides as Potent Inhibitors of Vascular Endothelial Growth Factor Receptors 1 and 2

Tumor angiogenesis has become an important target for antitumor therapy, with most current therapies aimed at blocking the vascular endothelial growth factor (VEGF) pathway. The VEGF and its receptors have been implicated as key factors in tumor angiogenesis and are major targets in cancer therapy. A series of aryl-modified benzoylamino-N-(5,6-dimethoxy-1H-benzoimidazol-2-yl)-heteroamides were synthesized from 2-amino-5,6-dimethoxy benzimidazole and aryl-substituted benzoylamino hetero acids. The new compounds were tested for inhibition of VEGF receptors I and II (VEGFR-1 and VEGFR-2). Compound 6e displayed VEGFR-2 inhibitory activity with a 50% inhibition concentration value as low as 0.020 μM in a homogeneous time-resolved fluorescence enzymatic assay. VEGFR-2 active compounds display good activity against VEGFR-1 as well.