(2R,3R)-2-(benhydrylideneamino)-1-(tert-butyldimethylsilanyloxy)tridecan-3-ol

Base Information

Chemical Name:(2R,3R)-2-(benhydrylideneamino)-1-(tert-butyldimethylsilanyloxy)tridecan-3-ol
CAS No.:377082-50-3
Molecular Formula:C₃₂H₅₁NO₂Si
Molecular Weight:509.848
Hs Code.:

Synonyms:(2R,3R)-2-(benhydrylideneamino)-1-(tert-butyldimethylsilanyloxy)tridecan-3-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-2-(benhydrylideneamino)-1-(tert-butyldimethylsilanyloxy)tridecan-3-ol

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Technology Process of (2R,3R)-2-(benhydrylideneamino)-1-(tert-butyldimethylsilanyloxy)tridecan-3-ol

There total 2 articles about (2R,3R)-2-(benhydrylideneamino)-1-(tert-butyldimethylsilanyloxy)tridecan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 17049-50-2
n-decyl magnesium bromide

: 208253-69-4
(R)-2-(Benzhydrylidene-amino)-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid methyl ester

: 377082-50-3
(2R,3R)-2-(benhydrylideneamino)-1-(tert-butyldimethylsilanyloxy)tridecan-3-ol

: (2R,3S)-2-(benzhydrylideneamino)-1-(tert-butyldimethylsilanyloxy)tridecan-3-ol

Guidance literature:: (R)-2-(Benzhydrylidene-amino)-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid methyl ester; With i-Bu₂AlH*i-Bu₃Al; In hexane; dichloromethane; at -78 ℃; for 0.75h;

n-decyl magnesium bromide; In diethyl ether; hexane; dichloromethane; at -78 - 20 ℃;
DOI:10.1021/jo015844v

Reference yield:

: 17049-50-2
n-decyl magnesium bromide

: 2-(benzhydrylidene-amino)-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid ethyl ester

: 377082-50-3
(2R,3R)-2-(benhydrylideneamino)-1-(tert-butyldimethylsilanyloxy)tridecan-3-ol

: (2R,3S)-2-(benzhydrylideneamino)-1-(tert-butyldimethylsilanyloxy)tridecan-3-ol

Guidance literature:: 2-(benzhydrylidene-amino)-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid ethyl ester; With i-Bu₂AlH*i-Bu₃Al; In hexane; dichloromethane; at -78 ℃; for 0.75h;

n-decyl magnesium bromide; In diethyl ether; hexane; dichloromethane; at -78 - 20 ℃; Further stages.;
DOI:10.1021/jo015844v

Reference yield:

: 377082-50-3
(2R,3R)-2-(benhydrylideneamino)-1-(tert-butyldimethylsilanyloxy)tridecan-3-ol

: 377082-62-7
(2R,3R)-carbonic acid benzyl ester 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxytridecyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: aq. HCl / tetrahydrofuran / 2 h / 20 °C

2: 110.1 mg / dioxane / 20 °C

3: 96 percent / DMAP; iPr₂NEt / CH₂Cl₂ / 48 h / -78 - 20 °C

With hydrogenchloride; dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jo015844v