(3-chloro-4-methoxy-benzyl)-[7-(2-methyl-allyloxy)-6-nitro-quinazolin-4-yl]-amine

Base Information

Chemical Name:(3-chloro-4-methoxy-benzyl)-[7-(2-methyl-allyloxy)-6-nitro-quinazolin-4-yl]-amine
CAS No.:1007308-66-8
Molecular Formula:C₂₀H₁₉ClN₄O₄
Molecular Weight:414.848
Hs Code.:

Synonyms:(3-chloro-4-methoxy-benzyl)-[7-(2-methyl-allyloxy)-6-nitro-quinazolin-4-yl]-amine

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Chemical Property of (3-chloro-4-methoxy-benzyl)-[7-(2-methyl-allyloxy)-6-nitro-quinazolin-4-yl]-amine

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Technology Process of (3-chloro-4-methoxy-benzyl)-[7-(2-methyl-allyloxy)-6-nitro-quinazolin-4-yl]-amine

There total 3 articles about (3-chloro-4-methoxy-benzyl)-[7-(2-methyl-allyloxy)-6-nitro-quinazolin-4-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1007308-61-3
4-(3-chloro-4-methoxy-benzylamino)-6-nitro-quinazolin-7-ol

: 513-42-8
3-hydroxy-2-methyl-1-propene

: 1007308-66-8
(3-chloro-4-methoxy-benzyl)-[7-(2-methyl-allyloxy)-6-nitro-quinazolin-4-yl]-amine

Guidance literature:: 4-(3-chloro-4-methoxy-benzylamino)-6-nitro-quinazolin-7-ol; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 0.166667h;

3-hydroxy-2-methyl-1-propene; In tetrahydrofuran; dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 53449-14-2
7-chloro-6-nitro-4(3H)-quinazolinone

: 1007308-66-8
(3-chloro-4-methoxy-benzyl)-[7-(2-methyl-allyloxy)-6-nitro-quinazolin-4-yl]-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / 17 h / 20 °C / Heating / reflux

2.1: triethylamine / N,N-dimethyl-formamide / isopropyl alcohol / 17 h / 20 °C

3.1: methanol / 16 h / Heating / reflux

4.1: lithium chloride / N,N-dimethyl-formamide / 5 h / 150 °C

5.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; dichloromethane / 0.17 h / 0 - 20 °C

5.2: 18 h / 20 °C

With thionyl chloride; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; lithium chloride; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 162012-71-7
4,7-dichloro-6-nitro-quinazoline

: 1007308-66-8
(3-chloro-4-methoxy-benzyl)-[7-(2-methyl-allyloxy)-6-nitro-quinazolin-4-yl]-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / N,N-dimethyl-formamide / isopropyl alcohol / 17 h / 20 °C

2.1: methanol / 16 h / Heating / reflux

3.1: lithium chloride / N,N-dimethyl-formamide / 5 h / 150 °C

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; dichloromethane / 0.17 h / 0 - 20 °C

4.2: 18 h / 20 °C

With di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; lithium chloride; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;