Boc-Tyr(Msib)-Gly-Gly-Phe-Met(O)-OMsib

Base Information

Chemical Name:Boc-Tyr(Msib)-Gly-Gly-Phe-Met(O)-OMsib
CAS No.:129398-73-8
Molecular Formula:C₄₈H₅₉N₅O₁₂S₃
Molecular Weight:994.221
Hs Code.:

Synonyms:Boc-Tyr(Msib)-Gly-Gly-Phe-Met(O)-OMsib

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Boc-Tyr(Msib)-Gly-Gly-Phe-Met(O)-OMsib

Chemical Property:

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Technology Process of Boc-Tyr(Msib)-Gly-Gly-Phe-Met(O)-OMsib

There total 11 articles about Boc-Tyr(Msib)-Gly-Gly-Phe-Met(O)-OMsib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 129398-75-0
Boc-Tyr(Msib)OSu

: Gly-Gly-Phe-Met(O)-OMsib

: 129398-73-8
Boc-Tyr(Msib)-Gly-Gly-Phe-Met(O)-OMsib

Guidance literature:: With 4-methyl-morpholine; triethylamine; In N,N-dimethyl-formamide;

Reference yield:

: 3446-90-0
4-(methylthio)benzyl alcohol

: 129398-73-8
Boc-Tyr(Msib)-Gly-Gly-Phe-Met(O)-OMsib

Guidance literature:: Multi-step reaction with 11 steps

1: 99 percent / trimethylsilyl bromide / CHCl₃ / 1 h / 0 °C

2: 75 percent / 30percent H₂O₂ / acetic acid / 20 h / 20 °C

3: 62 percent / dicyclohexylamine / dimethylformamide

4: TFA, anisole

5: 81 percent / Et₃N, N-methylmorpholine / dimethylformamide / 3 h

6: TFA, anisole

7: 98 percent / Et₃N, N-methylmorpholine / dimethylformamide / 3 h

8: TFA, anisole

9: 83 percent / Et₃N, N-methylmorpholine / 3 h

10: TFA, anisole

11: 68 percent / Et₃N, N-methylmorpholine / dimethylformamide

With 4-methyl-morpholine; trimethylsilyl bromide; dihydrogen peroxide; methoxybenzene; triethylamine; N-cyclohexyl-cyclohexanamine; trifluoroacetic acid; In chloroform; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 38185-19-2
4-(methylthio)benzyl bromide

: 129398-73-8
Boc-Tyr(Msib)-Gly-Gly-Phe-Met(O)-OMsib

Guidance literature:: Multi-step reaction with 10 steps

1: 75 percent / 30percent H₂O₂ / acetic acid / 20 h / 20 °C

2: 62 percent / dicyclohexylamine / dimethylformamide

3: TFA, anisole

4: 81 percent / Et₃N, N-methylmorpholine / dimethylformamide / 3 h

5: TFA, anisole

6: 98 percent / Et₃N, N-methylmorpholine / dimethylformamide / 3 h

7: TFA, anisole

8: 83 percent / Et₃N, N-methylmorpholine / 3 h

9: TFA, anisole

10: 68 percent / Et₃N, N-methylmorpholine / dimethylformamide

With 4-methyl-morpholine; dihydrogen peroxide; methoxybenzene; triethylamine; N-cyclohexyl-cyclohexanamine; trifluoroacetic acid; In acetic acid; N,N-dimethyl-formamide;