4-[3-(4-chloro-3-methoxyphenyl)-1-(4-aminophenyl)-1H-pyrazol-4-yl]pyridine

Base Information

Chemical Name:4-[3-(4-chloro-3-methoxyphenyl)-1-(4-aminophenyl)-1H-pyrazol-4-yl]pyridine
CAS No.:1350473-76-5
Molecular Formula:C₂₁H₁₇ClN₄O
Molecular Weight:376.845
Hs Code.:

Synonyms:4-[3-(4-chloro-3-methoxyphenyl)-1-(4-aminophenyl)-1H-pyrazol-4-yl]pyridine

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Chemical Property of 4-[3-(4-chloro-3-methoxyphenyl)-1-(4-aminophenyl)-1H-pyrazol-4-yl]pyridine

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Technology Process of 4-[3-(4-chloro-3-methoxyphenyl)-1-(4-aminophenyl)-1H-pyrazol-4-yl]pyridine

There total 7 articles about 4-[3-(4-chloro-3-methoxyphenyl)-1-(4-aminophenyl)-1H-pyrazol-4-yl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.4%

: 1350473-75-4
4-[3-(4-chloro-3-methoxyphenyl)-1-(4-nitrophenyl)-1H-pyrazol-4-yl]pyridine

: 1350473-76-5
4-[3-(4-chloro-3-methoxyphenyl)-1-(4-aminophenyl)-1H-pyrazol-4-yl]pyridine

Guidance literature:: With palladium on activated charcoal; hydrogen; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2011.08.013

Reference yield:

: 116022-18-5
methyl 4-chloro-3-methoxybenzoate

: 1350473-76-5
4-[3-(4-chloro-3-methoxyphenyl)-1-(4-aminophenyl)-1H-pyrazol-4-yl]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -25 - 20 °C

2.1: 18 h / 20 °C

2.2: 20 °C

3.1: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 8 h / 90 °C / Inert atmosphere

4.1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 2 h / 20 °C

With copper(l) iodide; palladium on activated charcoal; hydrogen; potassium carbonate; L-proline; lithium hexamethyldisilazane; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2011.08.013

Reference yield:

: 342435-01-2
1-(4-chloro-3-methoxyphenyl)-2-(pyridin-4-yl)ethanone

: 1350473-76-5
4-[3-(4-chloro-3-methoxyphenyl)-1-(4-aminophenyl)-1H-pyrazol-4-yl]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 18 h / 20 °C

1.2: 20 °C

2.1: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 8 h / 90 °C / Inert atmosphere

3.1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 2 h / 20 °C

With copper(l) iodide; palladium on activated charcoal; hydrogen; potassium carbonate; L-proline; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2011.08.013