Technology Process of (E)-methyl 2-(2-methoxy-5-((2',4',6'-trimethoxystyrylsulfonyl)methyl)phenylamino)propanoate
There total 14 articles about (E)-methyl 2-(2-methoxy-5-((2',4',6'-trimethoxystyrylsulfonyl)methyl)phenylamino)propanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Methyl 2-bromopropionate;
With
sodium acetate;
In
ethanol;
for 0.166667h;
Inert atmosphere;
Reflux;
(E)-2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)aniline;
In
ethanol;
for 48h;
Inert atmosphere;
Reflux;
DOI:10.1021/jm200570p
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide / methanol / 3 h / 20 °C / Inert atmosphere
2.1: dihydrogen peroxide; acetic acid / water / 24 h / 20 °C / Inert atmosphere
3.1: acetic acid; benzylamine / Inert atmosphere; Reflux
4.1: sodium dithionite / water; acetone / 1 h / 50 °C / Inert atmosphere
5.1: sodium acetate / ethanol / 0.17 h / Inert atmosphere; Reflux
5.2: 48 h / Inert atmosphere; Reflux
With
sodium dithionite; dihydrogen peroxide; sodium acetate; acetic acid; benzylamine; sodium hydroxide;
In
methanol; ethanol; water; acetone;
3.1: Knoevenagel condensation;
DOI:10.1021/jm200570p
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 18 h / Inert atmosphere; Reflux
2.1: sodium hydroxide / methanol / 3 h / 20 °C / Inert atmosphere
3.1: dihydrogen peroxide; acetic acid / water / 24 h / 20 °C / Inert atmosphere
4.1: acetic acid; benzylamine / Inert atmosphere; Reflux
5.1: sodium dithionite / water; acetone / 1 h / 50 °C / Inert atmosphere
6.1: sodium acetate / ethanol / 0.17 h / Inert atmosphere; Reflux
6.2: 48 h / Inert atmosphere; Reflux
With
N-Bromosuccinimide; sodium dithionite; dihydrogen peroxide; sodium acetate; acetic acid; benzylamine; sodium hydroxide; dibenzoyl peroxide;
In
methanol; tetrachloromethane; ethanol; water; acetone;
4.1: Knoevenagel condensation;
DOI:10.1021/jm200570p