6-(4-methyl-1-piperazinyl)-3-pyridinamine hydrochloride

Base Information

• Chemical Name: 6-(4-methyl-1-piperazinyl)-3-pyridinamine hydrochloride
• CAS No.: 1234971-67-5
• Molecular Formula: C₁₀H₁₆N₄*ClH
• Molecular Weight: 228.725
• Mol file: 1234971-67-5.mol

Synonyms:6-(4-methyl-1-piperazinyl)-3-pyridinamine hydrochloride

Chemical Property of 6-(4-methyl-1-piperazinyl)-3-pyridinamine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-methyl-1-piperazinyl)-3-pyridinamine hydrochloride

There total 1 articles about 6-(4-methyl-1-piperazinyl)-3-pyridinamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-methyl-4-(5-nitropyridin-2-yl)piperazine (55403-34-4) → 6-(4-methyl-1-piperazinyl)-3-pyridinamine hydrochloride (1234971-67-5,82205-57-0)

Guidance literature:

1-methyl-4-(5-nitropyridin-2-yl)piperazine; With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 3h;

With hydrogenchloride; In 1,4-dioxane; for 0.0833333h;

Reference yield: 58.0%

ethyl 2-((2-chloro-5-methyl-4-pyrimidinyl){[(1.1-dimethylethyl)oxy]carbonyl}amino)benzoate (1089653-99-5) + 6-(4-methyl-1-piperazinyl)-3-pyridinamine hydrochloride (1234971-67-5,82205-57-0) → ethyl 2-[{[(1,1-dimethylethyl)oxy]carbonyl}(5-methyl-2-{[6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino}-4-pyrimidinyl)amino]benzoate (1089654-00-1)

Guidance literature:

With caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 50 ℃; for 16.25h;

Reference yield: 46.0%

2-[(2-bromo-5-methyl-4-pyrimidinyl)amino]-N-(1-methylethyl)benzamide (1089653-88-2) + 6-(4-methyl-1-piperazinyl)-3-pyridinamine hydrochloride (1234971-67-5,82205-57-0) → N-(1-methylethyl)-2-[(5-methyl-2-{[6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino}-4-pyrimidinyl)amino]benzamide hydrochloride (1089653-37-1)

Guidance literature:

2-[(2-bromo-5-methyl-4-pyrimidinyl)amino]-N-(1-methylethyl)benzamide; 6-(4-methyl-1-piperazinyl)-3-pyridinamine hydrochloride; With caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 70 ℃; for 16h;

With hydrogenchloride; In 1,4-dioxane; methanol;

upstream raw materials:

1-methyl-4-(5-nitropyridin-2-yl)piperazine

Downstream raw materials:

2-[(5-chloro-2-{[6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino}-4-pyrimidinyl)amino]-N-methylbenzamide

N-methyl-2-[(5-methyl-2-{[6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino}-4-pyrimidinyl)amino]benzamide hydrochloride

2-[(5-fluoro-2-{[6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino}-4-pyrimidinyl)amino]-N-(1-methylethyl)benzamide hydrochloride

ethyl 2-[(5-methyl-2-{[6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino}-4-pyrimidinyl)amino]benzoate