Technology Process of 7-benzyloxy-2-[(4-tert-butoxycarbonylamino)phenyl]-1,2-dihydro-N,N-dimethyl-1-oxo-4-(3,4,5-trimethoxyphenyl)-3-isoquinolinecarboxamide
There total 9 articles about 7-benzyloxy-2-[(4-tert-butoxycarbonylamino)phenyl]-1,2-dihydro-N,N-dimethyl-1-oxo-4-(3,4,5-trimethoxyphenyl)-3-isoquinolinecarboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
at 20 ℃;
for 3h;
DOI:10.1021/jm000558h
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C
1.2: 81 percent / tetrahydrofuran / 0.5 h / -40 °C
2.1: 94 percent / 2 N HCl / tetrahydrofuran / 20 °C
3.1: 58 percent / resorcinol; acetate buffer; NaClO2 / dioxane; H2O / 20 °C / pH 3.8
4.1: K2CO3 / dimethylformamide / 20 °C
5.1: 4 N HCl / ethyl acetate / 20 °C
5.2: AcOH / dioxane / 6 h / Heating
6.1: 97 percent / 2 N aq. NaOH / tetrahydrofuran; methanol / 2 h / 20 °C
7.1: 74 percent / i-Pr2NEt / various solvent(s) / 8 h / 110 °C
8.1: 76 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole hydrate / 3 h / 20 °C
With
hydrogenchloride; sodium hydroxide; sodium chlorite; n-butyllithium; acetate buffer; potassium carbonate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; recorcinol;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm000558h
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C
1.2: 81 percent / tetrahydrofuran / 0.5 h / -40 °C
2.1: 94 percent / 2 N HCl / tetrahydrofuran / 20 °C
3.1: 58 percent / resorcinol; acetate buffer; NaClO2 / dioxane; H2O / 20 °C / pH 3.8
4.1: K2CO3 / dimethylformamide / 20 °C
5.1: 4 N HCl / ethyl acetate / 20 °C
5.2: AcOH / dioxane / 6 h / Heating
6.1: 97 percent / 2 N aq. NaOH / tetrahydrofuran; methanol / 2 h / 20 °C
7.1: 74 percent / i-Pr2NEt / various solvent(s) / 8 h / 110 °C
8.1: 76 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole hydrate / 3 h / 20 °C
With
hydrogenchloride; sodium hydroxide; sodium chlorite; n-butyllithium; acetate buffer; potassium carbonate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; recorcinol;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm000558h
