3-((1R,3R)-3-[6-benzenesulfonyl-2-((R)-1-hydroxyethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentyl)-propionitrile

Base Information

Chemical Name:3-((1R,3R)-3-[6-benzenesulfonyl-2-((R)-1-hydroxyethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentyl)-propionitrile
CAS No.:1418200-50-6
Molecular Formula:C₂₄H₂₅N₅O₃S
Molecular Weight:463.56
Hs Code.:

Synonyms:3-((1R,3R)-3-[6-benzenesulfonyl-2-((R)-1-hydroxyethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentyl)-propionitrile

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Chemical Property of 3-((1R,3R)-3-[6-benzenesulfonyl-2-((R)-1-hydroxyethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentyl)-propionitrile

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Technology Process of 3-((1R,3R)-3-[6-benzenesulfonyl-2-((R)-1-hydroxyethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentyl)-propionitrile

There total 11 articles about 3-((1R,3R)-3-[6-benzenesulfonyl-2-((R)-1-hydroxyethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentyl)-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1418200-04-0
3-((1R,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentyl)-propionitrile

: 1418200-50-6
3-((1R,3R)-3-[6-benzenesulfonyl-2-((R)-1-hydroxyethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentyl)-propionitrile

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1418200-02-8
(1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentanecarbaldehyde

: 1418200-50-6
3-((1R,3R)-3-[6-benzenesulfonyl-2-((R)-1-hydroxyethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentyl)-propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C

1.2: 1 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; In tetrahydrofuran; ethanol;

Reference yield:

: 1418200-03-9
3-((1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentyl)-acrylonitrile

: 1418200-50-6
3-((1R,3R)-3-[6-benzenesulfonyl-2-((R)-1-hydroxyethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentyl)-propionitrile

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; In tetrahydrofuran; ethanol;