(1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentanecarbaldehyde

Base Information

Chemical Name:(1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentanecarbaldehyde
CAS No.:1418200-02-8
Molecular Formula:C₂₈H₃₆N₄O₄SSi
Molecular Weight:552.77
Hs Code.:

Synonyms:(1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentanecarbaldehyde

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Chemical Property of (1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentanecarbaldehyde

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Technology Process of (1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentanecarbaldehyde

There total 8 articles about (1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentanecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1418200-18-6
((1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentyl)-methanol

: 1418200-02-8
(1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentanecarbaldehyde

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 1418200-13-1
(1S,3R)-3-(1-benzenesulfonyl-5-nitro-1H-pyrrolo[2,3-b]pyridin-4-ylamino)-cyclopentanecarboxylic acid

: 1418200-02-8
(1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentanecarbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 1 h / 60 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C

3.1: triethyloxonium fluoroborate / tetrahydrofuran / 1 h / 20 °C

3.2: 3 h / 90 °C

4.1: 1H-imidazole / dichloromethane / 20 °C

5.1: sodium tetrahydroborate / ethanol / 1 h / 20 °C

6.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C

With 1H-imidazole; sodium tetrahydroborate; thionyl chloride; palladium 10% on activated carbon; hydrogen; triethyloxonium fluoroborate; Dess-Martin periodane; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 1418200-17-5
(1S,3R)-3-(6-benzenesulfonyl-2-(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentanecarboxylic acid methyl ester

: 1418200-02-8
(1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentanecarbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 1 h / 20 °C

2: Dess-Martin periodane / dichloromethane / 0 - 20 °C

With sodium tetrahydroborate; Dess-Martin periodane; In ethanol; dichloromethane;