3-((1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentyl)-acrylonitrile

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Chemical Name:3-((1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentyl)-acrylonitrile
CAS No.:1418200-03-9
Molecular Formula:C₃₀H₃₇N₅O₃SSi
Molecular Weight:575.807
Hs Code.:

Synonyms:3-((1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentyl)-acrylonitrile

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Chemical Property of 3-((1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentyl)-acrylonitrile

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Technology Process of 3-((1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentyl)-acrylonitrile

There total 9 articles about 3-((1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentyl)-acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2537-48-6
diethyl 1-cyanomethylphosphonate

: 1418200-02-8
(1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentanecarbaldehyde

: 1418200-03-9
3-((1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentyl)-acrylonitrile

Guidance literature:: diethyl 1-cyanomethylphosphonate; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;

(1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentanecarbaldehyde; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 1418200-14-2
(1S,3R)-3-(1-benzenesulfonyl-5-nitro-1H-pyrrolo[2,3-b]pyridin-4-ylamino)-cyclopentanecarboxylic acid methyl ester

: 1418200-03-9
3-((1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentyl)-acrylonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C

2.1: triethyloxonium fluoroborate / tetrahydrofuran / 1 h / 20 °C

2.2: 3 h / 90 °C

3.1: 1H-imidazole / dichloromethane / 20 °C

4.1: sodium tetrahydroborate / ethanol / 1 h / 20 °C

5.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C

6.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C

6.2: 1 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; triethyloxonium fluoroborate; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 1418200-13-1
(1S,3R)-3-(1-benzenesulfonyl-5-nitro-1H-pyrrolo[2,3-b]pyridin-4-ylamino)-cyclopentanecarboxylic acid

: 1418200-03-9
3-((1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentyl)-acrylonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / 1 h / 60 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C

3.1: triethyloxonium fluoroborate / tetrahydrofuran / 1 h / 20 °C

3.2: 3 h / 90 °C

4.1: 1H-imidazole / dichloromethane / 20 °C

5.1: sodium tetrahydroborate / ethanol / 1 h / 20 °C

6.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C

7.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C

7.2: 1 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; thionyl chloride; palladium 10% on activated carbon; hydrogen; triethyloxonium fluoroborate; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; ethanol; dichloromethane;