5-Aminopyrazine-2-carboxamide

Base Information

• Chemical Name: 5-Aminopyrazine-2-carboxamide
• CAS No.: 89323-09-1
• Molecular Formula: C5H6 N4 O
• Molecular Weight: 138.129
• Hs Code.: 2934999090
• ChEMBL ID: CHEMBL3105664
• DSSTox Substance ID: DTXSID60502954
• Wikidata: Q82356387
• Mol file: 89323-09-1.mol

Synonyms:5-AMINOPYRAZINE-2-CARBOXAMIDE;89323-09-1;MFCD08705774;SCHEMBL2220140;CHEMBL3105664;DTXSID60502954;AKOS006290280;CS-W019230;DS-3936;SY113486;FT-0713196;W17933

Chemical Property of 5-Aminopyrazine-2-carboxamide

Chemical Property:

• PSA: 94.89000
• LogP: 0.43920
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: -1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 138.05416083
• Heavy Atom Count: 10
• Complexity: 138

Purity/Quality:

97% ^*data from raw suppliers

5-Aminopyrazine-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(N=CC(=N1)N)C(=O)N

Technology Process of 5-Aminopyrazine-2-carboxamide

There total 5 articles about 5-Aminopyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

5-chloro-pyrazine-2-carboxylic acid amide (21279-64-1) → 5-aminopyrazine-2-carboxamide (89323-09-1)

Guidance literature:

With ammonium hydroxide; In methanol; at 95 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.bmcl.2013.12.054

Reference yield:

5-amino-2-bromopyrazine (59489-71-3) + potassium cyanide (151-50-8) → 5-aminopyrazine-2-carboxamide (89323-09-1) + 5-amino-2-pyrazinecarboxylic acid (40155-43-9)

Guidance literature:

With ethanol;

DOI:10.1021/ja01176a058

Reference yield:

5-chloropyrazine-2-carbonyl chloride (88625-23-4) → 5-aminopyrazine-2-carboxamide (89323-09-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium hydroxide / dichloromethane / 2 h / 20 °C

2: ammonium hydroxide / methanol / 0.5 h / 95 °C / Microwave irradiation

With ammonium hydroxide; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2013.12.054

upstream raw materials:

5-amino-2-bromopyrazine

potassium cyanide

5-chloro-pyrazine-2-carboxylic acid amide

5-chloropyrazine-2-carbonyl chloride

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