(S)-(-)-2-chloro-2-phenethylacetic acid

Base Information

• Chemical Name: (S)-(-)-2-chloro-2-phenethylacetic acid
• CAS No.: 33942-00-6
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 198.649
• Mol file: 33942-00-6.mol

Synonyms:(S)-(-)-2-chloro-2-phenethylacetic acid

Chemical Property of (S)-(-)-2-chloro-2-phenethylacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(-)-2-chloro-2-phenethylacetic acid

There total 23 articles about (S)-(-)-2-chloro-2-phenethylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

chloro-trimethyl-silane (75-77-4) + 2-methoxy-2-methyl-4-phenyl-1,3-dioxolane (286967-46-2) → (S)-(-)-2-chloro-2-phenethylacetic acid (33942-00-6)

Guidance literature:

at -78 - 0 ℃;

DOI:10.1021/ja00279a059

Reference yield: 97.0%

styrene oxide (96-09-3) + acetyl chloride (75-36-5) → 1-acetoxy-2-chloro-2-phenylethane (33942-00-6,103590-74-5,6509-95-1)

Guidance literature:

With zinc(II) oxide; In dichloromethane; at 20 ℃; for 0.5h; regioselective reaction;

DOI:10.1002/hc.20529

Reference yield: 87.0%

styrene oxide (96-09-3) + acetic anhydride (108-24-7) → 1-acetoxy-2-chloro-2-phenylethane (33942-00-6,103590-74-5,6509-95-1)

Guidance literature:

With nickel(II) chloride hexahydrate; In ethanol; at 20 ℃; for 0.5h; Solvent; Temperature; regioselective reaction;

DOI:10.1002/aoc.4520

upstream raw materials:

acetyl chloride

trans-2,5-diphenyl-[1,4]dioxane

phenylethane 1,2-diol

2-acetoxy-2-methylpropanoyl chloride

Downstream raw materials:

Acetic acid 3,3-dicyano-2-phenyl-propyl ester

α-D-(2-hydroxyethyl)benzene

(R)-2-phenylethyl 4-methylbenzenesulfonate

(S)-(+)-1-phenylethane-1-d₁

Refernces

• 1、 Hassanzadeh, Shadi,Eisavi, Ronak,Abbasian, Mojtaba. "Preparation and characterization of magnetically separable MgFe2O4/Mg(OH)2 nanocomposite as an efficient heterogeneous catalyst for regioselective one-pot synthesis of β-chloroacetates from epoxides". . . Retrieved 2018/09/06.
• 2、 Wang, Zhentao,Zhu, Lin,Yin, Feng,Su, Zhongquan,Li, Zhaodong,Li, Chaozhong. "Silver-catalyzed decarboxylative chlorination of aliphatic carboxylic acids". experimental part. p. 4258 - 4263. Retrieved 2012/04/10.