(1S)-N₁-benzyl-N₄-[1-butyl-2-hydroxy-2-(5'-chloro-6'-methoxyl-2'-naphthyl)ethyl]piperazine

Base Information

• Chemical Name: (1S)-N₁-benzyl-N₄-[1-butyl-2-hydroxy-2-(5'-chloro-6'-methoxyl-2'-naphthyl)ethyl]piperazine
• CAS No.: 1221409-15-9
• Molecular Formula: C₂₈H₃₅ClN₂O₂
• Molecular Weight: 467.051

Synonyms:(1S)-N₁-benzyl-N₄-[1-butyl-2-hydroxy-2-(5'-chloro-6'-methoxyl-2'-naphthyl)ethyl]piperazine

Chemical Property of (1S)-N₁-benzyl-N₄-[1-butyl-2-hydroxy-2-(5'-chloro-6'-methoxyl-2'-naphthyl)ethyl]piperazine

Chemical Property:

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Technology Process of (1S)-N₁-benzyl-N₄-[1-butyl-2-hydroxy-2-(5'-chloro-6'-methoxyl-2'-naphthyl)ethyl]piperazine

There total 5 articles about (1S)-N₁-benzyl-N₄-[1-butyl-2-hydroxy-2-(5'-chloro-6'-methoxyl-2'-naphthyl)ethyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-bis(2-chloro-ethyl)-benzenemethanamine (55-51-6) + 2-amino-1-(5-chloro-6-methoxynaphthalen-2-yl)hexan-1-ol (1221409-52-4) → (1S)-N1-benzyl-N4-[1-butyl-2-hydroxy-2-(5'-chloro-6'-methoxyl-2'-naphthyl)ethyl]piperazine (1221409-15-9)

Guidance literature:

With triethylamine; In acetonitrile; for 20h; Reflux;

Reference yield:

(S)-2-[2-(1,3-dioxoisoindole)hexanoyl]-5-chloro-6-methoxylnaphthaline (1221409-48-8) → (1S)-N1-benzyl-N4-[1-butyl-2-hydroxy-2-(5'-chloro-6'-methoxyl-2'-naphthyl)ethyl]piperazine (1221409-15-9)

Guidance literature:

Multi-step reaction with 3 steps

1: aluminum isopropoxide / isopropyl alcohol; toluene / 4 h / 100 °C

2: hydrazine hydrate / methanol / 3 h / 20 °C

3: triethylamine / acetonitrile / 20 h / Reflux

With hydrazine hydrate; aluminum isopropoxide; triethylamine; In methanol; isopropyl alcohol; toluene; acetonitrile;

Reference yield:

L-Norleucine (327-57-1) → (1S)-N1-benzyl-N4-[1-butyl-2-hydroxy-2-(5'-chloro-6'-methoxyl-2'-naphthyl)ethyl]piperazine (1221409-15-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine / toluene / 24 h / 110 °C

2.1: oxalyl dichloride; pyridine / dichloromethane / 20 h / 0 - 20 °C

2.2: 3 h / 20 °C

3.1: aluminum isopropoxide / isopropyl alcohol; toluene / 4 h / 100 °C

4.1: hydrazine hydrate / methanol / 3 h / 20 °C

5.1: triethylamine / acetonitrile / 20 h / Reflux

With pyridine; oxalyl dichloride; hydrazine hydrate; aluminum isopropoxide; triethylamine; In methanol; dichloromethane; isopropyl alcohol; toluene; acetonitrile;

upstream raw materials:

N,N-bis(2-chloro-ethyl)-benzenemethanamine

2-amino-1-(5-chloro-6-methoxynaphthalen-2-yl)hexan-1-ol

L-Norleucine

(S)-2-(1,3-dioxoisoindolin-2-yl)hexanoic acid

Downstream raw materials:

(1S,2S)-2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl)hexan-1-ol

(1R,2S)-2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl)hexan-1-ol

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