2-(4-benzyloxy-5,7-difluoro-1H-indol-3-yl)-N,N-dimethylethanamine

Base Information

• Chemical Name: 2-(4-benzyloxy-5,7-difluoro-1H-indol-3-yl)-N,N-dimethylethanamine
• CAS No.: 1179983-75-5
• Molecular Formula: C₁₉H₂₀F₂N₂O
• Molecular Weight: 330.377
• Mol file: 1179983-75-5.mol

Synonyms:2-(4-benzyloxy-5,7-difluoro-1H-indol-3-yl)-N,N-dimethylethanamine

Chemical Property of 2-(4-benzyloxy-5,7-difluoro-1H-indol-3-yl)-N,N-dimethylethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-benzyloxy-5,7-difluoro-1H-indol-3-yl)-N,N-dimethylethanamine

There total 2 articles about 2-(4-benzyloxy-5,7-difluoro-1H-indol-3-yl)-N,N-dimethylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

2-(4-benzyloxy-5,7-difluoro-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide (1179983-74-4) → 2-(4-benzyloxy-5,7-difluoro-1H-indol-3-yl)-N,N-dimethylethanamine (1179983-75-5)

Guidance literature:

With lithium aluminium tetrahydride; In 1,4-dioxane; Reflux;

Reference yield:

4-Benzyloxyindol-3-yl-N,N-dimethylglyoxylamide (52061-51-5) → 2-(4-benzyloxy-5,7-difluoro-1H-indol-3-yl)-N,N-dimethylethanamine (1179983-75-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Selectfluor / acetonitrile / 20 °C

2: lithium aluminium tetrahydride / 1,4-dioxane / Reflux

With lithium aluminium tetrahydride; Selectfluor; In 1,4-dioxane; acetonitrile;

Reference yield: 62.0%

2-(4-benzyloxy-5,7-difluoro-1H-indol-3-yl)-N,N-dimethylethanamine (1179983-75-5) + methyl iodide (74-88-4) → 2-(4-(benzyloxy)-5,7-difluoro-1-methyl-1H-indol-3-yl)-N,N-dimethylethanamine (1179983-76-6)

Guidance literature:

2-(4-benzyloxy-5,7-difluoro-1H-indol-3-yl)-N,N-dimethylethanamine; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;

methyl iodide; In N,N-dimethyl-formamide;

upstream raw materials:

2-(4-benzyloxy-5,7-difluoro-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide

4-Benzyloxyindol-3-yl-N,N-dimethylglyoxylamide

Downstream raw materials:

2-(4-(benzyloxy)-5,7-difluoro-1-methyl-1H-indol-3-yl)-N,N-dimethylethanamine