N-(4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl)-1-piperazin-1-yl-2,3-dihydro-1H-indene-5-carboxamide

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Chemical Name:N-(4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl)-1-piperazin-1-yl-2,3-dihydro-1H-indene-5-carboxamide
CAS No.:1232061-78-7
Molecular Formula:C₃₀H₃₁N₇O
Molecular Weight:505.622
Hs Code.:

Synonyms:N-(4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl)-1-piperazin-1-yl-2,3-dihydro-1H-indene-5-carboxamide

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Chemical Property of N-(4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl)-1-piperazin-1-yl-2,3-dihydro-1H-indene-5-carboxamide

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Technology Process of N-(4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl)-1-piperazin-1-yl-2,3-dihydro-1H-indene-5-carboxamide

There total 7 articles about N-(4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl)-1-piperazin-1-yl-2,3-dihydro-1H-indene-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1232061-74-3
tert-Butyl 4-{5-[({4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}amino) carbonyl]-2,3-dihydro-1H-inden-1-yl}piperazin-1-carboxylate

: 1232061-78-7
N-(4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl)-1-piperazin-1-yl-2,3-dihydro-1H-indene-5-carboxamide

Guidance literature:: tert-Butyl 4-{5-[({4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}amino) carbonyl]-2,3-dihydro-1H-inden-1-yl}piperazin-1-carboxylate; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

pH=10; High performance liquid chromatography;

Reference yield:

: 34598-50-0
5-bromo-1-indanol

: 1232061-78-7
N-(4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl)-1-piperazin-1-yl-2,3-dihydro-1H-indene-5-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / dichloromethane / 4 h / 20 °C / Cooling with ice

2.1: sodium carbonate / acetonitrile / 60 °C

3.1: triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / ethanol; dimethyl sulfoxide / 24 h / 100 °C / Inert atmosphere

4.1: sodium hydroxide / methanol / 20 - 50 °C

4.2: pH 5

5.1: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

6.2: pH 10 / High performance liquid chromatography

With hydrogenchloride; thionyl chloride; sodium carbonate; triethylamine; HATU; sodium hydroxide; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In 1,4-dioxane; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1232062-52-0
tert-Butyl-4-(5-Bromo-2,3-dihydro-1H-inden-1-yl) piperazin-1-carboxylate

: 1232061-78-7
N-(4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl)-1-piperazin-1-yl-2,3-dihydro-1H-indene-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / ethanol; dimethyl sulfoxide / 24 h / 100 °C / Inert atmosphere

2.1: sodium hydroxide / methanol / 20 - 50 °C

2.2: pH 5

3.1: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

4.2: pH 10 / High performance liquid chromatography

With hydrogenchloride; triethylamine; HATU; sodium hydroxide; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In 1,4-dioxane; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;