tert-Butyl 4-{5-[({4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}amino) carbonyl]-2,3-dihydro-1H-inden-1-yl}piperazin-1-carboxylate

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Chemical Name:tert-Butyl 4-{5-[({4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}amino) carbonyl]-2,3-dihydro-1H-inden-1-yl}piperazin-1-carboxylate
CAS No.:1232061-74-3
Molecular Formula:C₃₅H₃₉N₇O₃
Molecular Weight:605.74
Hs Code.:

Synonyms:tert-Butyl 4-{5-[({4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}amino) carbonyl]-2,3-dihydro-1H-inden-1-yl}piperazin-1-carboxylate

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Chemical Property of tert-Butyl 4-{5-[({4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}amino) carbonyl]-2,3-dihydro-1H-inden-1-yl}piperazin-1-carboxylate

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Technology Process of tert-Butyl 4-{5-[({4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}amino) carbonyl]-2,3-dihydro-1H-inden-1-yl}piperazin-1-carboxylate

There total 6 articles about tert-Butyl 4-{5-[({4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}amino) carbonyl]-2,3-dihydro-1H-inden-1-yl}piperazin-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1232062-60-0
1-[4-(BOC) piperazin-1-yl]-2,3-dihydro-1H-indene-5-carboxylic acid

: 152460-10-1
6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

: 1232061-74-3
tert-Butyl 4-{5-[({4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}amino) carbonyl]-2,3-dihydro-1H-inden-1-yl}piperazin-1-carboxylate

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 34598-50-0
5-bromo-1-indanol

: 1232061-74-3
tert-Butyl 4-{5-[({4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}amino) carbonyl]-2,3-dihydro-1H-inden-1-yl}piperazin-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / dichloromethane / 4 h / 20 °C / Cooling with ice

2.1: sodium carbonate / acetonitrile / 60 °C

3.1: triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / ethanol; dimethyl sulfoxide / 24 h / 100 °C / Inert atmosphere

4.1: sodium hydroxide / methanol / 20 - 50 °C

4.2: pH 5

5.1: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

With thionyl chloride; sodium carbonate; triethylamine; HATU; sodium hydroxide; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 158330-91-7
5-bromo-1-chloro-indane

: 1232061-74-3
tert-Butyl 4-{5-[({4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}amino) carbonyl]-2,3-dihydro-1H-inden-1-yl}piperazin-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / acetonitrile / 60 °C

2.1: triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / ethanol; dimethyl sulfoxide / 24 h / 100 °C / Inert atmosphere

3.1: sodium hydroxide / methanol / 20 - 50 °C

3.2: pH 5

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

With sodium carbonate; triethylamine; HATU; sodium hydroxide; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;