5-BROMO-1-CHLOROINDANE

Base Information

• Chemical Name: 5-BROMO-1-CHLOROINDANE
• CAS No.: 158330-91-7
• Molecular Formula: C9H8BrCl
• Molecular Weight: 231.51700
• Hs Code.: 2903999090
• Mol file: 158330-91-7.mol

Synonyms:5-bromo-1-chloro-indane;QC-5195;5-bromo-1-chloro-indan;

Chemical Property of 5-BROMO-1-CHLOROINDANE

Chemical Property:

• PSA: 0.00000
• LogP: 3.67520
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-1-chloro-2,3-dihydro-1H-indene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-1-CHLOROINDANE

There total 2 articles about 5-BROMO-1-CHLOROINDANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-bromo-1-indanol (34598-50-0) → 5-bromo-1-chloro-indane (158330-91-7)

Guidance literature:

With thionyl chloride; In dichloromethane; at -10 - 20 ℃; for 14h;

Reference yield:

5-Bromo-1-indanone (34598-49-7) → 5-bromo-1-chloro-indane (158330-91-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / methanol

2: SOCl₂ / toluene

With sodium tetrahydroborate; thionyl chloride; In methanol; toluene;

DOI:10.1016/S0960-894X(02)00945-9

Reference yield: 61.0%

trimethylsilyl cyanide (7677-24-9) + 5-bromo-1-chloro-indane (158330-91-7) → 5-bromo-2,3-dihydro-1H-indene-1-carbonitrile (1188174-30-2)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at 20 ℃; for 5h;

upstream raw materials:

5-bromo-1-indanol

5-Bromo-1-indanone

Downstream raw materials:

(3S)-methyl 3-(4-(5-bromo-2,3-dihydro-1H-inden-1-yloxy)phenyl)hex-4-ynoate

methyl 3-(4-(5-bromo-2,3-dihydro-1H-inden-1-yloxy)phenyl)-3-(1H-pyrazol-1-yl)propanoate

tert-Butyl 4-{5-[({4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}amino) carbonyl]-2,3-dihydro-1H-inden-1-yl}piperazin-1-carboxylate

N-(4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl)-1-piperazin-1-yl-2,3-dihydro-1H-indene-5-carboxamide

Refernces

• 1、 -. "A novel benzoyl amide compounds". Paragraph 0131-0133. . Retrieved 2016/11/21.
• 2、 -. "PREPARATION METHOD OF DIHYDROINDENE AMIDE COMPOUNDS THEIR PHARMACEUTICAL COMPOSITIONS CONTAING COMPOUNDS THEREOF AND USE AS PROTEIN KINASES INHIBITOR". Page/Page column 14. . Retrieved 2011/11/13.