methyl 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}-2-nitrobenzoate

Base Information

Chemical Name:methyl 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}-2-nitrobenzoate
CAS No.:913078-83-8
Molecular Formula:C₂₅H₂₅F₃N₂O₈S
Molecular Weight:570.543
Hs Code.:

Synonyms:methyl 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}-2-nitrobenzoate

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Chemical Property of methyl 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}-2-nitrobenzoate

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Technology Process of methyl 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}-2-nitrobenzoate

There total 11 articles about methyl 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}-2-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 135964-75-9
methyl 4-(hydroxymethyl)-2-nitrobenzoate

: 913078-78-1
N-[2-hydroxy-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide

: 913078-83-8
methyl 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}-2-nitrobenzoate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; for 3h;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 209688-18-6
2-nitro-5-trifluoromethylphenyl methoxymethyl ether

: 913078-83-8
methyl 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}-2-nitrobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / hydrogen / palladium on carbon / methanol / 1 h

2: 92 percent / pyridine / CH₂Cl₂ / 6 h / 20 °C

3: 63 percent / potassium carbonate / dimethylformamide / 80 °C

4: 94 percent / HCl / methanol; dioxane / 6 h

5: 80 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 3 h

With pyridine; hydrogenchloride; hydrogen; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 5: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 402-17-5
2-nitro-5-trifluoromethylphenol

: 913078-83-8
methyl 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}-2-nitrobenzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / hydrogen / palladium on carbon / methanol / 1 h

2: 92 percent / pyridine / CH₂Cl₂ / 6 h / 20 °C

3: 63 percent / potassium carbonate / dimethylformamide / 80 °C

4: 94 percent / HCl / methanol; dioxane / 6 h

5: 80 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 3 h

With pyridine; hydrogenchloride; hydrogen; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 6: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.06.067