2-[4'-(2-oxo-2-piperidin-1-yl-ethyl)-biphenyl-4-yl]-1-piperidin-1-yl-ethanone

Base Information

Chemical Name:2-[4'-(2-oxo-2-piperidin-1-yl-ethyl)-biphenyl-4-yl]-1-piperidin-1-yl-ethanone
CAS No.:855256-71-2
Molecular Formula:C₂₆H₃₂N₂O₂
Molecular Weight:404.552
Hs Code.:

Synonyms:2-[4'-(2-oxo-2-piperidin-1-yl-ethyl)-biphenyl-4-yl]-1-piperidin-1-yl-ethanone

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Chemical Property of 2-[4'-(2-oxo-2-piperidin-1-yl-ethyl)-biphenyl-4-yl]-1-piperidin-1-yl-ethanone

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Technology Process of 2-[4'-(2-oxo-2-piperidin-1-yl-ethyl)-biphenyl-4-yl]-1-piperidin-1-yl-ethanone

There total 3 articles about 2-[4'-(2-oxo-2-piperidin-1-yl-ethyl)-biphenyl-4-yl]-1-piperidin-1-yl-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 110-89-4
piperidine

: 19806-14-5
<1,1'-biphenyl>-4,4'-diacetic acid

: 855256-71-2
2-[4'-(2-oxo-2-piperidin-1-yl-ethyl)-biphenyl-4-yl]-1-piperidin-1-yl-ethanone

Guidance literature:: <1,1'-biphenyl>-4,4'-diacetic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 130 ℃; for 0.0833333h; under 7500.6 Torr; microwave irradiation;

piperidine; In tetrahydrofuran; at 130 ℃; for 0.0833333h; under 7500.6 Torr; microwave irradiation;
DOI:10.1016/j.bmcl.2006.04.092

Reference yield:

: 1667-10-3
4,4'-bis(chloromethyl)biphenyl

: 855256-71-2
2-[4'-(2-oxo-2-piperidin-1-yl-ethyl)-biphenyl-4-yl]-1-piperidin-1-yl-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 97 percent / acetonitrile / 0.08 h / 150 °C / 7500.6 Torr / microwave irradiation

2.1: 92 percent / KOH / ethanol / 0.08 h / 150 °C / 7500.6 Torr / microwave irradiation

3.1: CDI / tetrahydrofuran / 0.08 h / 130 °C / 7500.6 Torr / microwave irradiation

3.2: 77 percent / tetrahydrofuran / 0.08 h / 130 °C / 7500.6 Torr / microwave irradiation

With potassium hydroxide; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1016/j.bmcl.2006.04.092

Reference yield:

: 7255-83-6
4,4’-bis(cyanomethyl)-1,1’biphenyl

: 855256-71-2
2-[4'-(2-oxo-2-piperidin-1-yl-ethyl)-biphenyl-4-yl]-1-piperidin-1-yl-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 92 percent / KOH / ethanol / 0.08 h / 150 °C / 7500.6 Torr / microwave irradiation

2.1: CDI / tetrahydrofuran / 0.08 h / 130 °C / 7500.6 Torr / microwave irradiation

2.2: 77 percent / tetrahydrofuran / 0.08 h / 130 °C / 7500.6 Torr / microwave irradiation

With potassium hydroxide; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmcl.2006.04.092