19806-14-5

Usage

Uses

Used in Pharmaceutical Industry:
2-[4-[4-(carboxymethyl)phenyl]phenyl]acetic acid is used as a key intermediate in the synthesis of pharmaceuticals for its ability to form esters, amides, and other derivatives. Its structural features facilitate interactions with biological targets, making it a valuable component in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 2-[4-[4-(carboxymethyl)phenyl]phenyl]acetic acid serves as a fundamental building block for the creation of various agrochemicals. Its versatility in forming different chemical structures allows it to be utilized in the development of pesticides, herbicides, and other agricultural chemicals to improve crop protection and yield.

Upstream product

• 7255-83-6 4,4’-bis(cyanomethyl)-1,1’biphenyl 
• 57186-86-4 diethyl <1,1'-biphenyl>-4,4'-diacetate 
• 1667-10-3 4,4'-bis(chloromethyl)biphenyl 
• 201230-82-2 carbon monoxide 
• 92-52-4 biphenyl 
• 42094-63-3 4,4'-Bis-(2,2,2-trichloro-ethyl)-biphenyl 
• 105077-03-0 [4'-(Ethoxycarbonyl-methylsulfanyl-methyl)-biphenyl-4-yl]-methylsulfanyl-acetic acid ethyl ester 
• 25848-29-7 diethyl 4,4’-bis(phenylglyoxylate) 
• 92-86-4 4-(4-bromophenyl)bromobenzene 
• 92-87-5 p,p'-diaminobiphenyl 

Downstream Products

• 106064-78-2 DL-4,4'-Biphenylylenbis<<(thiobenzoyl)thio>essigsaeure> 
• 106064-89-5 5,5'-(4,4'-Biphenylylen)bis(2-phenyl-1,3-dithiolylium-4-olat) 
• 855256-71-2 2-[4'-(2-oxo-2-piperidin-1-yl-ethyl)-biphenyl-4-yl]-1-piperidin-1-yl-ethanone 

Relevant academic research and scientific papers

Hydrophilic microporous lanthanide-organic frameworks based on 4,4′-biphenyldiacetate: Synthesis, crystal structures and sorption properties

Fifteen microporous coordination polymers of symmetrical and flexible 4,4′-biphenyldiacetate (bpda2–) with lanthanide(III) cations (Ln3+) of formula {[Ln2(bpda)3(H2O)]?2H2O}n(Ln?=?La (1), Ce (2), Pr (3), Nd (4), Sm (5), Eu (6), Gd (7), Tb (8), Dy (9), Ho (10), Er (11), Tm (12), Yb (13), Lu (14), Y (15)), have been synthesized and characterized. Single crystal X-ray diffraction (for 1, 3 and 4) in combination with powder X-ray diffraction showed isostructural compounds with an infinite secondary building unit (SBU). In this SBU, two crystallographically independent lanthanide ions are connected by three carboxylate groups in chelating-bridging mode to zig-zag Ln-carboxylate chains. These chains are assembled by the biphenyl part of the ligand to a 3D network with water molecules in channels with rectangular cross-sections of ～1.6?×?3??2. Thermogravimetric analysis indicates complete removal of the water molecules at 150?°C and thermal stability up to 380?°C. Stability studies on compound 1 show no degeneration in crystallinity after refluxing in water or different organic solvents. The dehydrated compound 1 exhibited no N2or H2uptake at 77?K and no CH4or CO2uptake at 273?K up to 1?bar. High-pressure (17?bar, 273?K) CO2uptake of dehydrated [Ln2(bpda)3]ncorresponded to the formation of {[Ln2(bpda)3]·CO2}nwith about 40% of the adsorbed CO2retained upon desorption. Water vapor sorption of activated and hygroscopic [Ln2(bpda)3]nreformed {[Ln2(bpda)3(H2O)]·2H2O}n. 4,4′-Biphenyldiacetic acid (H2bpda) shows blue emission, its europium 6 and terbium 8 compounds show red and weak green luminescence under UV light irradiation, with the bpda2?ligand acting as an antenna ligand for the europium(III) ions.

Dibasic non-imidazole histamine H3 receptor antagonists with a rigid biphenyl scaffold

A class of rigid, dibasic, non-imidazole H3 antagonists was developed, starting from a series of previously described flexible compounds. The original polymethylene chain between two tertiary amine groups was replaced by a rigid scaffold, compo

Non-planar oligoarylene macrocycles from biphenyl

Saddle- and propeller-shaped macrocycles are obtained by fourfold Perkin condensations in transient high dilution of 4,4′-bis(phenylglyoxylic acid) with either 4,4′-bis(phenylacetic acid) or p-phenylenediacetic acid, followed by four-fold oxidative photoc

The selenium-containing complexes in the phenylacetic acid and its derivatives or its application in the synthesis of (by machine translation)

The present invention provides a kind of structural formula (I) indicated by the 2 - (2 - carboxyl phenyl) benzothiazole of selenium-containing complexes of, this kind of selenium-containing complex can be applied to the catalytic benzyl chloride rigid synthetic phenylacetic acid or derivatives thereof in the reaction, in the reaction, the less the amount of catalyst, the catalytic activity is high, simple operation, conducive to such synthetic method in industry popularization and application. (by machine translation)

An efficiently cobalt-catalyzed carbonylative approach to phenylacetic acid derivatives

A highly efficient cobalt-catalyzed carbonylative approach to phenylacetic acid derivatives under one atmosphere pressure is reported. This methodology represents a useful extension of benzimidazole used as ligand in metal catalysis, and the catalytic mechanism has been proved by computer simulation. Notably, this new cobalt precatalyst, which promotes the carbonylation reaction dramatically and has already been used for scale-up experiment of phenylacetic acid derivatives.

Cubic octanuclear Ni(II) clusters in highly porous polypyrazolyl-based materials

Two highly porous coordination polymers, containing rare octanuclear hydroxo-nickel clusters and long bis-pyrazolyl spacers, are shown to possess, after mild thermal treatment, lattice cavities up to 72% of the total crystal volume.

Synthesis and structure-activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity

The combination of antagonism at histamine H3 receptors and inhibition of acetylcholinesterase has been recently proposed as an approach to devise putative new therapeutic agents for cognitive diseases. The 4,4′-biphenyl fragment has been repor

Syntheses of Arenediacetic Esters and Acetonyl-Substituted Arylacetic Esters by Means of Friedel-Crafts Reaction with α-Acyl-α-chlorosulfides

Friedel-Crafts reaction of the phenylacetates 5a, b with ethyl α-chloro-α-(methylthio)acetate (1) in the presence of stannic chloride gave the α-methylthio-1,4-benzenediacetates 7a, b.The reactions of biphenyl, diphenylmethane, and diphenyl ether with an excess amount of 1 gave directly the corresponding disubstituted products 10a-c.Desulfurization of 7a, b and 10a-c gave the corresponding diacetates 8a, b and 11a-c.Methyl 4-(2-oxopropyl)phenylacetate (14) was prepared by reaction of methyl phenylacetate with α-chloro-α-(methylthio)acetone (2) followed by desulfurization of the resulting product.Methyl 2-(2-furyl)propionate (19) reacted with 2 in the presence of zinc chloride to give the 2,5-disubstituted furan 20, whose desulfurization gave methyl 2-propionate (21).Keywords - arenediacetic ester; Friedel-Crafts reaction; α-chlorosulfide; nonactic acid; nonactin; desulfurization; Raney nickel; stannic chloride; zinc chloride