4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide

Base Information

Chemical Name:4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide
CAS No.:1073969-37-5
Molecular Formula:C₂₃H₂₉FN₄O₃
Molecular Weight:428.507
Hs Code.:

Synonyms:4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide

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Chemical Property of 4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide

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Technology Process of 4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide

There total 2 articles about 4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1073973-06-4
4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-indazol-1-yl)-2,6-difluoro-benzonitrile

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: 1073969-37-5
4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide

Guidance literature:: 4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-indazol-1-yl)-2,6-difluoro-benzonitrile; (1S,2S)-2-aminocyclopentanol hydrochloride; With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 50 ℃;

With sodium hydroxide; water; dihydrogen peroxide; In methanol; dimethyl sulfoxide; at 50 ℃;

Reference yield: 8.0%

: 67-56-1
methanol

: 1073973-06-4
4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-indazol-1-yl)-2,6-difluoro-benzonitrile

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: 1073969-37-5
4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide

: 1073969-71-7
4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclopentylamino)-6-methoxybenzamide

Guidance literature:: 4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-indazol-1-yl)-2,6-difluoro-benzonitrile; (1S,2S)-2-aminocyclopentanol hydrochloride; With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 50 ℃; for 18h;

With sodium hydroxide; water; dihydrogen peroxide; In dimethyl sulfoxide; at 50 ℃; for 2h;

methanol; With sodium hydroxide; dihydrogen peroxide; In dimethyl sulfoxide; at 70 ℃; for 1h;