N-trimethylsilyl-N-p-methoxyphenyl-1-trifluoromethyl-2,2-difluoroethenamine

Base Information

• Chemical Name: N-trimethylsilyl-N-p-methoxyphenyl-1-trifluoromethyl-2,2-difluoroethenamine
• CAS No.: 881011-71-8
• Molecular Formula: C₁₃H₁₆F₅NOSi
• Molecular Weight: 325.354

Synonyms:N-trimethylsilyl-N-p-methoxyphenyl-1-trifluoromethyl-2,2-difluoroethenamine

Chemical Property of N-trimethylsilyl-N-p-methoxyphenyl-1-trifluoromethyl-2,2-difluoroethenamine

Chemical Property:

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Technology Process of N-trimethylsilyl-N-p-methoxyphenyl-1-trifluoromethyl-2,2-difluoroethenamine

There total 2 articles about N-trimethylsilyl-N-p-methoxyphenyl-1-trifluoromethyl-2,2-difluoroethenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

chloro-trimethyl-silane (75-77-4) + 4-methoxy-N-<2,2,2-trifluoro-1-(trifluoromethyl)ethylidene>benzeneamine (34025-21-3) → N-trimethylsilyl-N-p-methoxyphenyl-1-trifluoromethyl-2,2-difluoroethenamine (881011-71-8)

Guidance literature:

With magnesium; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1021/ol0526726

Reference yield:

4-methoxy-aniline (104-94-9) → N-trimethylsilyl-N-p-methoxyphenyl-1-trifluoromethyl-2,2-difluoroethenamine (881011-71-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: CH₂Cl₂ / -40 °C

1.2: 58 percent / Et₃N; POCl₃ / CH₂Cl₂ / Heating

2.1: 95 percent / Mg / tetrahydrofuran / 0.5 h / 0 °C

With magnesium; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol0526726

Reference yield: 90.0%

N-trimethylsilyl-N-p-methoxyphenyl-1-trifluoromethyl-2,2-difluoroethenamine (881011-71-8) → N-[2-bromo-2,2-difluoro-1-(trifluoromethyl)ethylidene]-p-anisidine

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; at 20 ℃;

DOI:10.1021/jo070719q

upstream raw materials:

chloro-trimethyl-silane

4-methoxy-N-<2,2,2-trifluoro-1-(trifluoromethyl)ethylidene>benzeneamine

4-methoxy-aniline

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