6-amino-1,4-dihydro-4-oxo-2-[(phenylmethyl)thio]-5-pyrimidinyl ester thiocyanic acid

Base Information

• Chemical Name: 6-amino-1,4-dihydro-4-oxo-2-[(phenylmethyl)thio]-5-pyrimidinyl ester thiocyanic acid
• CAS No.: 259103-40-7
• Molecular Formula: C₁₂H₁₀N₄OS₂
• Molecular Weight: 290.37

Synonyms:6-amino-1,4-dihydro-4-oxo-2-[(phenylmethyl)thio]-5-pyrimidinyl ester thiocyanic acid

Chemical Property of 6-amino-1,4-dihydro-4-oxo-2-[(phenylmethyl)thio]-5-pyrimidinyl ester thiocyanic acid

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Technology Process of 6-amino-1,4-dihydro-4-oxo-2-[(phenylmethyl)thio]-5-pyrimidinyl ester thiocyanic acid

There total 6 articles about 6-amino-1,4-dihydro-4-oxo-2-[(phenylmethyl)thio]-5-pyrimidinyl ester thiocyanic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

potassium thioacyanate (333-20-0) + 4-amino-2-(benzylthio)-6-hydroxypyrimidine (37660-23-4) → {[4-amino-2-(benzylsulfanyl)-6-hydroxypyrimidin-5-yl]sulfanyl}formonitrile (259103-40-7)

Guidance literature:

With bromine; In N,N-dimethyl-formamide; at 65 ℃;

DOI:10.1016/j.bmcl.2019.126807

Reference yield:

6-Amino-2-[(phenylmethyl)thio]-4(1H)-pyrimidinone (37660-23-4) + potassium thioacyanate (333-20-0) → 6-amino-1,4-dihydro-4-oxo-2-[(phenylmethyl)thio]-5-pyrimidinyl ester thiocyanic acid (259103-40-7)

Guidance literature:

With bromine;

Reference yield:

6-Amino-2-[(phenylmethyl)thio]-4(1H)-pyrimidinone (37660-23-4) → 6-amino-1,4-dihydro-4-oxo-2-[(phenylmethyl)thio]-5-pyrimidinyl ester thiocyanic acid (259103-40-7)

Guidance literature:

With pyridine; bromine; In N-methyl-acetamide;

upstream raw materials:

potassium thioacyanate

4-amino-2-(benzylthio)-6-hydroxypyrimidine

benzyl bromide

6-Amino-2-[(phenylmethyl)thio]-4(1H)-pyrimidinone

Downstream raw materials:

7-chloro-5-[(2,3-difluorobenzyl)sulfanyl][1,3]thiazolo[4,5-d]pyrimidin-2-amine

2-amino-5-(2,3-difluoro-benzylsulfanyl)-thiazolo[4,5-d]pyrimidin-7-ol

7-chloro-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-2-amine

2-amino-5-(benzylsulfanyl)[1,3]thiazolo[4,5-d]pyrimidin-7-ol

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