4(S)-<3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl>tetrahydro-2(S)-furanmethanol benzoate

Base Information

Chemical Name:4(S)-<3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl>tetrahydro-2(S)-furanmethanol benzoate
CAS No.:143191-79-1
Molecular Formula:C₁₆H₁₆N₂O₅
Molecular Weight:316.313
Hs Code.:

Synonyms:4(S)-<3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl>tetrahydro-2(S)-furanmethanol benzoate

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Chemical Property of 4(S)-<3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl>tetrahydro-2(S)-furanmethanol benzoate

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Technology Process of 4(S)-<3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl>tetrahydro-2(S)-furanmethanol benzoate

There total 21 articles about 4(S)-<3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl>tetrahydro-2(S)-furanmethanol benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 143191-76-8
1,4-anhydro-5-O-benzoyl-3-deoxy-2-O-p-toluenesulfonyl-D-ribitol

: 66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6
uracil

: 143191-79-1
2(S)-(O-benzoylmethyl)-4(S)-<3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl>tetrahydrofuran

Guidance literature:: With 18-crown-6 ether; potassium carbonate; In N,N-dimethyl-formamide; at 75 ℃; for 11h;
DOI:10.1016/S0040-4020(01)85259-5

Reference yield: 26.0%

: 66-22-8,51953-14-1
2,4-dihydroxypyrimidine

: 143191-76-8
1,4-anhydro-5-O-benzoyl-3-deoxy-2-O-p-toluenesulfonyl-D-ribitol

: 143191-79-1
4(S)-<3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl>tetrahydro-2(S)-furanmethanol benzoate

Guidance literature:: With 18-crown-6 ether; potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 20h;

Reference yield:

: 143191-75-7
2(S)-(O-benzoylmethyl)tetrahydrofuran-4(R)-ol

: 143191-79-1
4(S)-<3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl>tetrahydro-2(S)-furanmethanol benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂

2: NaN₃ / dimethylformamide / 55 °C

3: H₂ / Pd/C / ethanol; ethyl acetate

4: toluene

5: H₂SO₄ / dioxane / 100 °C

With sodium azide; sulfuric acid; hydrogen; triethylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm025569k