t-butyl (1-(4-bromo-1H-pyrazol-1-yl)-2-(3-nitrophenyl)propan-2-yl)carbamate

Base Information

Chemical Name:t-butyl (1-(4-bromo-1H-pyrazol-1-yl)-2-(3-nitrophenyl)propan-2-yl)carbamate
CAS No.:1397683-35-0
Molecular Formula:C₁₇H₂₁BrN₄O₄
Molecular Weight:425.282
Hs Code.:

Synonyms:t-butyl (1-(4-bromo-1H-pyrazol-1-yl)-2-(3-nitrophenyl)propan-2-yl)carbamate

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Chemical Property of t-butyl (1-(4-bromo-1H-pyrazol-1-yl)-2-(3-nitrophenyl)propan-2-yl)carbamate

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Technology Process of t-butyl (1-(4-bromo-1H-pyrazol-1-yl)-2-(3-nitrophenyl)propan-2-yl)carbamate

There total 5 articles about t-butyl (1-(4-bromo-1H-pyrazol-1-yl)-2-(3-nitrophenyl)propan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 2075-45-8
4-bromo-1H-pyrazole

: 1397683-33-8
tert-butyl 4-methyl-4-(3-nitrophenyl)-1,2,3-oxathiazolidine-3-carboxylate-2,2-dioxide

: 1397683-35-0
t-butyl (1-(4-bromo-1H-pyrazol-1-yl)-2-(3-nitrophenyl)propan-2-yl)carbamate

Guidance literature:: 4-bromo-1H-pyrazole; tert-butyl 4-methyl-4-(3-nitrophenyl)-1,2,3-oxathiazolidine-3-carboxylate-2,2-dioxide; With sodium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 2h;

With water; In N,N-dimethyl-formamide;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1397683-35-0
t-butyl (1-(4-bromo-1H-pyrazol-1-yl)-2-(3-nitrophenyl)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C

2.1: thionyl chloride / acetonitrile / 0.5 h / -40 °C / Inert atmosphere

2.2: 64 h / -40 - 20 °C / Inert atmosphere

3.1: ruthenium trichloride; sodium periodate / water; acetonitrile / 2 h / 0 - 20 °C

4.1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 130 °C

With ruthenium trichloride; sodium periodate; thionyl chloride; sodium hydrogencarbonate; sodium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acsmedchemlett.9b00181

Reference yield:

: 1397683-93-0
C₁₄H₁₈N₂O₆S

: 1397683-35-0
t-butyl (1-(4-bromo-1H-pyrazol-1-yl)-2-(3-nitrophenyl)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: ruthenium trichloride; sodium periodate / water; acetonitrile / 2 h / 0 - 20 °C

2: sodium carbonate / N,N-dimethyl-formamide / 2 h / 130 °C

With ruthenium trichloride; sodium periodate; sodium carbonate; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acsmedchemlett.9b00181