ethyl 4-bromo-1-(2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl)propyl)-1H-pyrazole-5-carboxylate

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Chemical Name:ethyl 4-bromo-1-(2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl)propyl)-1H-pyrazole-5-carboxylate
CAS No.:1397683-47-4
Molecular Formula:C₂₀H₂₅BrN₄O₆
Molecular Weight:497.346
Hs Code.:

Synonyms:ethyl 4-bromo-1-(2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl)propyl)-1H-pyrazole-5-carboxylate

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Chemical Property of ethyl 4-bromo-1-(2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl)propyl)-1H-pyrazole-5-carboxylate

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Technology Process of ethyl 4-bromo-1-(2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl)propyl)-1H-pyrazole-5-carboxylate

There total 7 articles about ethyl 4-bromo-1-(2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl)propyl)-1H-pyrazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1397683-35-0
t-butyl (1-(4-bromo-1H-pyrazol-1-yl)-2-(3-nitrophenyl)propan-2-yl)carbamate

: 541-41-3
chloroformic acid ethyl ester

: 1397683-47-4
ethyl 4-bromo-1-(2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl)propyl)-1H-pyrazole-5-carboxylate

Guidance literature:: t-butyl (1-(4-bromo-1H-pyrazol-1-yl)-2-(3-nitrophenyl)propan-2-yl)carbamate; With lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; ethylbenzene; at -78 ℃; for 1h;

chloroformic acid ethyl ester; In tetrahydrofuran; cyclohexane; ethylbenzene; at -78 - -50 ℃; for 1h;
DOI:10.1021/acsmedchemlett.9b00181

Reference yield: 65.0%

: 1397683-47-4
ethyl 4-bromo-1-(2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl)propyl)-1H-pyrazole-5-carboxylate

Guidance literature:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1397683-47-4
ethyl 4-bromo-1-(2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl)propyl)-1H-pyrazole-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C

2.1: thionyl chloride / acetonitrile / 0.5 h / -40 °C / Inert atmosphere

2.2: 64 h / -40 - 20 °C / Inert atmosphere

3.1: ruthenium trichloride; sodium periodate / water; acetonitrile / 2 h / 0 - 20 °C

4.1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 130 °C

5.1: lithium diisopropyl amide / tetrahydrofuran; cyclohexane; ethylbenzene / 1 h / -78 °C

5.2: 1 h / -78 - -50 °C

With ruthenium trichloride; sodium periodate; thionyl chloride; sodium hydrogencarbonate; sodium carbonate; lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; ethylbenzene; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acsmedchemlett.9b00181