7-[(4-cyclopropylphenyl)acetyl]-2-(5-pyrimidin-2-yl-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonane

Base Information

Chemical Name:7-[(4-cyclopropylphenyl)acetyl]-2-(5-pyrimidin-2-yl-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonane
CAS No.:1334783-34-4
Molecular Formula:C₃₁H₃₄N₄O
Molecular Weight:478.637
Hs Code.:

Synonyms:7-[(4-cyclopropylphenyl)acetyl]-2-(5-pyrimidin-2-yl-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonane

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Chemical Property of 7-[(4-cyclopropylphenyl)acetyl]-2-(5-pyrimidin-2-yl-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonane

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Technology Process of 7-[(4-cyclopropylphenyl)acetyl]-2-(5-pyrimidin-2-yl-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonane

There total 3 articles about 7-[(4-cyclopropylphenyl)acetyl]-2-(5-pyrimidin-2-yl-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 40641-90-5
2-(4-cyclopropylphenyl)acetic acid

: 2-(5-pyrimidin-2-yl-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonane dihydrochloride

: 1334783-34-4
7-[(4-cyclopropylphenyl)acetyl]-2-(5-pyrimidin-2-yl-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonane

Guidance literature:: With triethylamine; HATU; In dichloromethane; at 20 ℃;

Reference yield:

: 1097870-73-9
methyl 2-(4-cyclopropylphenyl)acetate

: 1334783-34-4
7-[(4-cyclopropylphenyl)acetyl]-2-(5-pyrimidin-2-yl-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonane

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / tetrahydrofuran; methanol / 45 °C

1.2: pH 3

2.1: triethylamine; HATU / dichloromethane / 20 °C

With water; triethylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 63349-52-0
methyl 4-iodophenylacetate

: 1334783-34-4
7-[(4-cyclopropylphenyl)acetyl]-2-(5-pyrimidin-2-yl-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonane

Guidance literature:: Multi-step reaction with 3 steps

1.1: tricyclohexylphosphine; potassium phosphate; palladium diacetate / toluene; water / 10 h / 100 °C / Inert atmosphere

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 45 °C

2.2: pH 3

3.1: triethylamine; HATU / dichloromethane / 20 °C

With potassium phosphate; water; palladium diacetate; triethylamine; HATU; sodium hydroxide; tricyclohexylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; toluene;