40641-90-5Relevant articles and documents
USE OF T-TYPE CALCIUM CHANNEL BLOCKER FOR TREATING PRURITUS
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Paragraph 0186-0188; 0266-0268, (2022/02/19)
A medicament for treating or preventing pruritus is provided. For the medicament for treating or preventing pruritus, a compound having a blocking action on Cav3.2T-type calcium channels represented by General Formulas (I) to (VI), a tautomer of the compo
COMBINATIONS OF AKT INHIBITOR COMPOUNDS AND VEMURAFENIB, AND METHODS OF USE
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, (2012/10/18)
The invention provides a combination of a) a compound of Formula Ia: [insert Formula Ia], or a pharmaceutically acceptable salt thereof, and b) vemurafenib or a pharmaceutically acceptable salt thereof for the prophylactic or therapeutic treatment of a hy
Pyridyl amides as potent inhibitors of T-type calcium channels
Reger, Thomas S.,Yang, Zhi-Qiang,Schlegel, Kelly-Ann S.,Shu, Youheng,Mattern, Christa,Cube, Rowena,Rittle, Kenneth E.,McGaughey, Georgia B.,Hartman, George D.,Tang, Cuyue,Ballard, Jeanine,Kuo, Yuhsin,Prueksaritanont, Thomayant,Nuss, Cindy E.,Doran, Scott M.,Fox, Steven V.,Garson, Susan L.,Li, Yuxing,Kraus, Richard L.,Uebele, Victor N.,Renger, John J.,Barrow, James C.
, p. 1692 - 1696 (2011/05/11)
A novel series of amide T-type calcium channel antagonists were prepared and evaluated using in vitro and in vivo assays. Optimization of the screening hit 3 led to identification of the potent and selective T-type antagonist 37 that displayed in vivo eff