2N-{4-[(1-ethoxy-2-methyl-1-oxopropan-2-yl)oxy]-3,5-dimethylbenzyl}-N-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)-methyl]glycine

Base Information

• Chemical Name: 2N-{4-[(1-ethoxy-2-methyl-1-oxopropan-2-yl)oxy]-3,5-dimethylbenzyl}-N-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)-methyl]glycine
• CAS No.: 866718-44-7
• Molecular Formula: C₂₈H₃₄N₂O₆
• Molecular Weight: 494.588
• Mol file: 866718-44-7.mol

Synonyms:2N-{4-[(1-ethoxy-2-methyl-1-oxopropan-2-yl)oxy]-3,5-dimethylbenzyl}-N-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)-methyl]glycine

Chemical Property of 2N-{4-[(1-ethoxy-2-methyl-1-oxopropan-2-yl)oxy]-3,5-dimethylbenzyl}-N-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)-methyl]glycine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2N-{4-[(1-ethoxy-2-methyl-1-oxopropan-2-yl)oxy]-3,5-dimethylbenzyl}-N-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)-methyl]glycine

There total 2 articles about 2N-{4-[(1-ethoxy-2-methyl-1-oxopropan-2-yl)oxy]-3,5-dimethylbenzyl}-N-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)-methyl]glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-[2,6-dimethyl-4-({[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]amino}methyl)phenoxy]-2-methylpropanoate (866640-93-9) + Glyoxilic acid (298-12-4) → 2N-{4-[(1-ethoxy-2-methyl-1-oxopropan-2-yl)oxy]-3,5-dimethylbenzyl}-N-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)-methyl]glycine (866718-44-7)

Guidance literature:

With sodium tris(acetoxy)borohydride; In methanol; at 20 ℃;

DOI:10.1248/cpb.c15-00221

Reference yield:

ethyl 2-[4-({(2-tert-butoxy-2-oxoethyl)[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate (866640-85-9) → 2N-{4-[(1-ethoxy-2-methyl-1-oxopropan-2-yl)oxy]-3,5-dimethylbenzyl}-N-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)-methyl]glycine (866718-44-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 14h;

Reference yield:

2N-{4-[(1-ethoxy-2-methyl-1-oxopropan-2-yl)oxy]-3,5-dimethylbenzyl}-N-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)-methyl]glycine (866718-44-7) + methylamine (74-89-5) → 2-[2,6-dimethyl-4-[[methylcarbamoylmethyl-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]phenoxy]-2-methylpropanoic acid ethyl ester

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 13h;

upstream raw materials:

ethyl 2-[4-({(2-tert-butoxy-2-oxoethyl)[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate

2-[2,6-dimethyl-4-({[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]amino}methyl)phenoxy]-2-methylpropanoate

Glyoxilic acid

Downstream raw materials:

2-[4-[[[2-(N'-tert-butoxycarbonylhydrazino)-2-oxoethyl]-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid ethyl ester

2-[4-[[[(2-hydroxy-1-methylethylcarbamoyl)methyl](5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid ethyl ester

2-[4-({[2-(cyclopropylamino)-2-oxoethyl][(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoic acid