(S)-(2-chloroethyl) O-ethyl phenylphosphonothioate

Base Information

• Chemical Name: (S)-(2-chloroethyl) O-ethyl phenylphosphonothioate
• CAS No.: 20384-93-4
• Molecular Formula: C₁₀H₁₄ClO₂PS
• Molecular Weight: 264.713
• Mol file: 20384-93-4.mol

Synonyms:(S)-(2-chloroethyl) O-ethyl phenylphosphonothioate

Chemical Property of (S)-(2-chloroethyl) O-ethyl phenylphosphonothioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(2-chloroethyl) O-ethyl phenylphosphonothioate

There total 4 articles about (S)-(2-chloroethyl) O-ethyl phenylphosphonothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-Chloroethanesulfonyl chloride (1622-32-8) + ethyl Phenylphosphinate (172487-18-2,2511-09-3) → (S)-(2-chloroethyl) O-ethyl phenylphosphonothioate (20384-93-4)

Guidance literature:

With copper(II) choride dihydrate; L-proline; In tetrahydrofuran; at 80 ℃; for 3h;

Reference yield:

ethanol (64-17-5) + Phenylthiophosphonsaeure-S-<2-chlor-aethylester>-chlorid (19051-10-6) → (S)-(2-chloroethyl) O-ethyl phenylphosphonothioate (20384-93-4)

Guidance literature:

With triethylamine; In chloroform; at 50 ℃; for 5h; Yield given;

Reference yield:

phenylphosphonothioic-di(2-chloroethyl)ester (6344-04-3) → (S)-(2-chloroethyl) O-ethyl phenylphosphonothioate (20384-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃ / 17 h / 85 °C

2: Et₃N / CHCl₃ / 5 h / 50 °C

With triethylamine; trichlorophosphate; In chloroform;

upstream raw materials:

2-chloroethyl sulfenyl chloride

diethyl phenylphosphonite

ethanol

Phenylthiophosphonsaeure-S-<2-chlor-aethylester>-chlorid